Journal ArticleDOI
The Efficacy of Influenza Vaccination in Elderly Individuals: A Randomized Double-blind Placebo-Controlled Trial
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In the elderly, influenza vaccination may halve the incidence of serological and clinical influenza (in periods of antigenic drift), which is less pronounced for self-reported influenza.Abstract:
Objective. —To determine the efficacy of influenza vaccination in elderly people. Design. —Randomized double-blind placebo-controlled trial. Setting. —Fifteen family practices in the Netherlands during influenza season 1991-1992. Participants. —A total of 1838 subjects aged 60 years or older, not known as belonging to those high-risk groups in which vaccination was previously given. Intervention. —Purified split-virion vaccine containing A/Singapore/6/86(H1N1), A/Beijing/353/89(H3N2), B/Beijing/1/87, and B/Panama/45/90 (n=927) or intramuscular placebo containing physiological saline solution (n=911). Main Outcome Measures. —Patients presenting with influenzalike illness up to 5 months after vaccination; self-reported influenza in postal questionnaires 10 weeks and 5 months after vaccination; serological influenza (fourfold increase of antibody titer between 3 weeks and 5 months after vaccination). Results. —The incidence of serological influenza was 4% in the vaccine group and 9% in the placebo group (relative risk [RR], 0.50; 95% confidence interval [CI], 0.35 to 0.61). The incidences of clinical influenza were 2% and 3%, respectively (RR, 0.53; 95% CI, 0.39 to 0.73). The effect was strongest for the combination of serological and clinical influenza (RR, 0.42; 95% CI, 0.23 to 0.74). The effect was less pronounced for self-reported influenza. Conclusion. —In the elderly, influenza vaccination may halve the incidence of serological and clinical influenza (in periods of antigenic drift). (JAMA. 1994;272:1661-1665)read more
Citations
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Low frequency of fires from alcohol-based hand rub dispensers in healthcare facilities.
John M. Boyce,Michele L. Pearson +1 more
TL;DR: A web-based questionnaire to SHEA, APIC, and EIN members to assess the frequency of fires associated with alcohol-based hand rub (ABHR) dispensers in healthcare settings found none of the 798 responding facilities using ABHRs reported a dispenser-related fire.
Journal ArticleDOI
Efficacy of antibiotics against influenza-like illness in an influenza epidemic
TL;DR: To determine if an antibiotic reduces the incidence of complications associated with influenza‐like illness during an influenza epidemic, a large number of patients treated with an antibiotic did not suffer from influenza-like illness.
Journal ArticleDOI
Impact of influenza vaccination on healthcare utilization - A systematic review.
TL;DR: The data suggests that the vaccine may result in a reduction of healthcare utilization in the older population, and high heterogeneity between studies hindered the aggregation of data into a meta-analysis.
Journal ArticleDOI
Effectiveness of the 2010 and 2011 Southern Hemisphere trivalent inactivated influenza vaccines against hospitalization with influenza-associated acute respiratory infection among Thai adults aged ≥ 50 years.
Fatimah S. Dawood,Prabda Prapasiri,Peera Areerat,Asadang Ruayajin,Malinee Chittaganpitch,Charung Muangchana,Henry C. Baggett,Sonja J. Olsen +7 more
TL;DR: A test‐negative case–control analysis is conducted to estimate 2010 and 2011 trivalent IIV effectiveness against hospitalization with influenza‐associated acute respiratory infection (ARI) among persons aged ≥50 years in rural Thailand.
Journal ArticleDOI
Geriatric health maintenance
TL;DR: The efficacy of many screening tests and interventions for preventing illness in elderly patients is unclear and as the general population continues to age, further research in this area will be important.
References
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Journal ArticleDOI
Epidemiologic Research: Principles and Quantitative Methods.
TL;DR: In this article, the authors present an overview of the main issues in epidemiology research and propose a method for controlling extraneous factors in the context of epidemiological studies, using Logistic Regression with Interaction, Effect Modification, and synergy.
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Epidemiologic Research: Principles and Quantitative Methods
TL;DR: In this article, the authors present an overview of the main issues in epidemiology research and propose a method for controlling extraneous factors in the context of epidemiological studies, using Logistic Regression with Interaction, Effect Modification, and synergy.
Journal ArticleDOI
Efficacy of Influenza Vaccine in Nursing Homes: Reduction in Illness and Complications During an Influenza A (H3N2) Epidemic
Peter A. Patriarca,Judith A. Weber,Robert A. Parker,William N. Hall,Alan P. Kendal,Dennis J. Bregman,Lawrence B. Schonberger +6 more
TL;DR: It is suggested that influenza vaccine can reduce the incidence and severity of influenza virus infections among the elderly and chronically ill and underscore the importance of vaccination programs for those in nursing homes and in the general community.
Journal ArticleDOI
Impact of epidemic type a influenza in a defined adult population
TL;DR: The authors study the occurrence of excess morbidity and mortality among subsets of the adult population of a large prepaid group practice during two epidemics of type A influenza to provide a basis for increasing the precision of clinical and public decision-making regarding the prevention of serious consequences of epidemic influenza.
Journal ArticleDOI
Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital.
TL;DR: It is suggested that annual revaccination with inactivated influenza-A vaccine confers no long-term advantage.