Journal ArticleDOI
The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children
Robert B. Belshe,Paul M. Mendelman,John J. Treanor,James C. King,William C. Gruber,Pedro A. Piedra,David I. Bernstein,Frederick G. Hayden,Karen L. Kotloff,Kenneth M. Zangwill,Dominick Iacuzio,Mark Wolff +11 more
TLDR
A live attenuated, cold-adapted, trivalent influenzavirus vaccine was safe, immunogenic, and effective against influenza A(H3N2) and B in healthy children.Abstract:
Background Influenzavirus vaccine is used infrequently in healthy children, even though the rates of influenza in this group are high. We conducted a multicenter, double-blind, placebo-controlled trial of a live attenuated, cold-adapted, trivalent influenzavirus vaccine in children 15 to 71 months old. Methods Two hundred eighty-eight children were assigned to receive one dose of vaccine or placebo given by intranasal spray, and 1314 were assigned to receive two doses approximately 60 days apart. The strains included in the vaccine were antigenically equivalent to those in the inactivated influenzavirus vaccine in use at the time. The subjects were monitored with viral cultures for influenza during the subsequent influenza season. A case of influenza was defined as an illness associated with the isolation of wild-type influenzavirus from respiratory secretions. Results The intranasal vaccine was accepted and well tolerated. Among children who were initially seronegative, antibody titers increased by a fac...read more
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Prevention and control of influenza : recommendations of the Advisory Committee on Immunization Practices (ACIP)
TL;DR: This report updates the 2000 recommendations by the Advisory Committee on Immunization Practices on the use of influenza vaccine and antiviral agents with new or updated information regarding the cost-effectiveness of influenza vaccination and the 2001-2002 trivalent vaccine virus strains.
Journal Article
Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009.
Anthony E. Fiore,Timothy M. Uyeki,Karen R. Broder,Lyn Finelli,Gary L. Euler,James A. Singleton,John K. Iskander,Pascale M. Wortley,David K. Shay,Joseph S. Bresee,Nancy J. Cox +10 more
TL;DR: This report updates the 2008 recommendations by CDC's Advisory Committee on Immunization Practices regarding the use of influenza vaccine for the prevention and control of seasonal influenza and includes a summary of safety data for U.S. licensed influenza vaccines.
Journal ArticleDOI
Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
TL;DR: Influenza vaccines can provide moderate protection against virologically confirmed influenza, but such protection is greatly reduced or absent in some seasons.
Journal ArticleDOI
Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2020-21 Influenza Season.
Lisa A. Grohskopf,Leslie Z. Sokolow,Leslie Z. Sokolow,Sonja J. Olsen,Joseph S. Bresee,Karen R. Broder,Ruth A. Karron +6 more
TL;DR: This report updates the 2017–18 recommendations of the Advisory Committee on Immunization Practices regarding the use of seasonal influenza vaccines in the United States and focuses on the recommendations for use of vaccines for the prevention and control of influenza during the 2018–19 season.
Journal ArticleDOI
The Diagnosis and Management of Acute Otitis Media
E. Tunkel,M. Rosenfeld,Xavier Sevilla,Richard H. Schwartz,Pauline A. Thomas,Mary Anne Jackson,Mark D. Joffe,Donald T. Miller,S. Lieberthal,Aaron E. Carroll,Theodore G. Ganiats +10 more
TL;DR: This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) andAmerican Academy of Family Physicians and provides recommendations to primary care clinicians for the management of children from 6 months through 12 years of age with uncomplicated AOM.
References
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Journal Article
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TL;DR: The Behavioral Risk Factor Surveillance System (BRFSS) is a state-based telephone survey of the civilian, non-institutionalized, adult (persons > or =18 years of age) population.
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TL;DR: The finding that live virus vaccine induced relatively long-lasting antibody in both local and serum compartments suggested that this vaccine may be a suitable alternative to inactivated vaccine for use in healthy persons.
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Journal ArticleDOI
Immunity to Influenza A Virus Infection in Young Children: A Comparison of Natural Infection, Live Cold-Adapted Vaccine, and Inactivated Vaccine
TL;DR: Prechallenge nasal IgA, detected almost exclusively in subjects naturally infected or vaccinated with live ca virus, was associated with protection and inactivated vaccine failed to produce significant local IgA during the primary response, but seemed to prime for secondary local antibody responses after challenge with liveca virus.