The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis
Barbara Tóth,Péter Hegyi,Tamás Lantos,Zsolt Szakács,Beáta Kerémi,Gábor Varga,Judit Tenk,Erika Pétervári,Márta Balaskó,Zoltan Rumbus,Zoltán Rakonczay,Emese Réka Bálint,Tivadar Kiss,Dezső Csupor +13 more
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TLDR
A literature review of currently available published randomized, controlled clinical trials to give an up-to-date evaluation of the efficacy of saffron in mild to moderate depression, compared to placebo or routinely used antidepressants finds that saffrons has a significant effect on the severity of depression.Abstract:
Herbal products, especially Hypericum perforatum extracts, have been widely used as first-line treatments for mild to moderate depression. Recently, several randomized, controlled clinical trials have been conducted to evaluate the efficacy of another plant, saffron (Crocus sativus), in mild to moderate depression. We have carried out a literature review of currently available published randomized, controlled clinical trials to give an up-to-date evaluation of the efficacy of saffron in mild to moderate depression, compared to placebo or routinely used antidepressants. The meta-analysis is reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines using the PICO (patients, intervention, comparison, outcome) format and was conducted using the statistical programs Comprehensive Meta-analysis and RevMan. PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases were searched for relevant studies. Only placebo or active controlled, randomized clinical studies involving patients suffering from mild to moderate depression and using pharmacological doses of saffron per os were included. Hedgesʼ g was used to calculate effect sizes. Risk of bias was assessed using the Cochrane Collaboration tool, and heterogeneity was tested by both performing the Cochranʼs Q test and calculating Higginsʼ I2
indicator. Eleven randomized trials were included in the qualitative analysis, and nine were pooled for statistical analysis. According to the present meta-analysis, saffron has a significant effect on the severity of depression. Available data from randomized, controlled clinical trials support that saffron is significantly more effective than placebo (g = 0.891; 95% CI: 0.369 – 1.412, p = 0.001), and non-inferior to tested antidepressant drugs (g = − 0.246; 95% CI: − 0.495 – 0.004, p = 0.053).read more
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An efficient framework for conducting systematic literature reviews in agricultural sciences
TL;DR: This study attempts to develop a framework for systematic review with guidelines on how to conduct an effective systematic review for agricultural research and finds that in the last two decades about a third of the eligible studies, classified as reviews related to agricultural research, are available as free full-text from publisher.
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Saffron (Crocus sativus L.) in ocular diseases: a narrative review of the existing evidence from clinical studies
TL;DR: A narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.
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Nutritional and health beneficial properties of saffron (Crocus sativus L): a comprehensive review.
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TL;DR: This plant and its active compounds could be a beneficial medicinal food ingredient in the formation of drugs targeting nervous system disorders, and multiple preclinical and clinical studies have supported neuroprotective, anxiolytic, antidepressant, learning and memory-enhancing effect of saffron and its bioactive constituents.
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Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation.
Peeraphong Lertnimitphun,Yiwen Jiang,Nami Kim,Wenwei Fu,Changwu Zheng,Hongsheng Tan,Hua Zhou,Xue Zhang,Weizhong Pei,Yue Lu,Hong-Xi Xu +10 more
TL;DR: Safranal alleviated clinical symptoms in the DSS-induced colitis model, and colon histology showed decreased severity of inflammation, depth of inflammatory involvement, and crypt damage.
Book ChapterDOI
Saffron (Crocus sativus L.): phytochemistry, therapeutic significance and omics-based biology
TL;DR: This chapter will present a glimpse of the current status, origin, history, distribution, production, folk uses, phytochemistry, therapeutics of saffron, and progress made in Crocus sativus genomics, metabolomics, transcriptomics, metagenomics, bioinformatics, miRNomics, etc., while their integratome omics approach will provide a useful framework.
References
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Journal Article
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
TL;DR: The QUOROM Statement (QUality Of Reporting Of Meta-analyses) as mentioned in this paper was developed to address the suboptimal reporting of systematic reviews and meta-analysis of randomized controlled trials.
Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
TL;DR: A structured summary is provided including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings.
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.