Journal ArticleDOI
The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes.
Scott A. Sands,Scott A. Sands,Kimberly J. Reid,Kimberly J. Reid,Sheryl L. Windsor,Sheryl L. Windsor,William S. Harris,William S. Harris +7 more
Reads0
Chats0
TLDR
Four factors significantly and independently influenced the Omega-3 Index: fish servings, age, BMI, and diabetes; and further studies are warranted to delineate the nondietary factors that influence RBC EPA + DHA content.Abstract:
n−3 FA are beneficial for cardiovascular health, reducing platelet aggregation, TG levels, and the risk of sudden death from myocardial infarction. The percentage of EPA + DHA in red blood cells (RBC), also known as the Omega-3 Index, has recently been proposed as a risk marker for death from coronary heart disease (CHD). The purpose of this study was to begin to explore the factors that can influence RBC EPA + DHA. We collected information on the number of servings of tuna or nonfried fish consumed per month, as well as on age, gender, ethnicity, smoking status, the presence of diabetes, and body mass index (BMI) in 163 adults in Kansas City who were not taking fish oil supplements. The average RBC EPA + DHA in this population was 4.9±2.1%. On a multivariate analysis, four factors significantly and independently influenced the Omega-3 Index: fish servings, age, BMI, and diabetes. The Index increased by 0.24 units with each additional monthly serving of tuna or nonfried fish (P<0.0001), and by 0.5 units for each additional decade in age (P<0.0001). The Index was 1.13% units lower in subjects with diabetes (P=0.015) and decreased by 0.3% units with each 3-unit increase in BMI (P=0.001). Gender or smoking status had no effect, and the univariate relationship with ethnicity vanished after controlling for deathfrom CHD, further studies are warranted to delineate the nondietary factors that influence RBC EPA + DHA content.read more
Citations
More filters
Journal ArticleDOI
DHA Effects in Brain Development and Function.
Lotte Lauritzen,Paola Brambilla,Alessandra Mazzocchi,Laurine B. S. Harsløf,Valentina Ciappolino,Carlo Agostoni +5 more
TL;DR: A narrative review on research on the associations between DHA levels and brain development and function throughout the lifespan suggests a role of DHA in cognitive decline and in relation to major psychiatric disorders.
Journal ArticleDOI
Omega-3 Fatty Acids and Cardiovascular Disease: A Case for Omega-3 Index as a New Risk Factor
TL;DR: The omega-3 index fulfils many of the requirements for a risk factor including consistent epidemiological evidence, a plausible mechanism of action, a reproducible assay, independence from classical risk factors, modifiability, and most importantly, the demonstration that raising tissue levels will reduce risk for cardiac events.
Journal ArticleDOI
Effects of fish-oil supplementation on myocardial fatty acids in humans
Robert G. Metcalf,Michael J. James,Robert A. Gibson,James Edwards,John Stubberfield,Robert Stuklis,Kurt C. Roberts-Thomson,Glenn D. Young,Leslie G. Cleland +8 more
TL;DR: The results of the present study show that dietary n-3 fatty acids are rapidly incorporated into human myocardial phospholipids at the expense of arachidonic acid during high-dose fish-oil supplementation.
Journal ArticleDOI
SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.
Giovanni Malerba,Linda Schaeffer,Luciano Xumerle,Norman Klopp,Elisabetta Trabetti,M. Biscuola,Ugo Cavallari,Roberta Galavotti,Nicola Martinelli,Patrizia Guarini,Domenico Girelli,Oliviero Olivieri,Roberto Corrocher,Joachim Heinrich,Pier Franco Pignatti,Thomas Illig +15 more
TL;DR: The observed strong association of FADS gene polymorphisms with the levels of arachidonic acid, which is a precursor of molecules involved in inflammation and immunity processes, suggests that SNPs of the FADS1 and FADS2 gene region are worth studying in diseases related to inflammatory conditions or alterations in the concentration of PUFAs.
Journal ArticleDOI
EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls.
TL;DR: Odds for ACS case status increased incrementally as the EPA-DHA content decreased suggesting that low EPA+DHA may be associated with increased risk for ACS.
References
More filters
Journal ArticleDOI
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
TL;DR: Evidence from epidemiological studies and RCTs will be reviewed, and recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation.
Journal Article
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.
Journal ArticleDOI
Sudden death due to cardiac arrhythmias.
TL;DR: This review article summarizes important changes in the approach to the serious public health problem of sudden death from ventricular arrhythmias.
Journal ArticleDOI
n-3 fatty acids and serum lipoproteins: human studies.
TL;DR: Great care must be taken not only to use appropriate animal models when studying lipoprotein metabolism but also to feed the animals comparable amounts of n-3 fatty acids, because failure to properly address these issues will make it difficult to uncover the biochemical basis for the hypolipidemic effect of fish oils in humans through use of experimental animals.
Related Papers (5)
The Omega-3 Index: a new risk factor for death from coronary heart disease?
Dietary Intake and Cell Membrane Levels of Long-Chain n-3 Polyunsaturated Fatty Acids and the Risk of Primary Cardiac Arrest
David S. Siscovick,Trivellore E. Raghunathan,Irena B. King,Sheila Weinmann,Kristine G. Wicklund,Jennifer Albright,Viktor E. Bovbjerg,Patrick G. Arbogast,Heidi Smith,Lawrence H. Kushi,Leonard A. Cobb,Michael K. Copass,Bruce M. Psaty,Rozenn N. Lemaitre,Barbara M. Retzlaff,Marian T. Childs,Robert H. Knopp +16 more