Journal ArticleDOI
The impact of stress on the development and expression of atopy
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TLDR
Examination of other mechanisms (e.g. oxidative stress pathways, glucocorticoid resistance, nerve–mast cell interactions, intestinal dysbiosis) and a broader range of cytokines and neuropeptides produced by cells both within and outside the immune system may better delineate the true complexity of the underlying mechanisms linking stress to allergic sensitization and asthma.Abstract:
Summary Psychological stress may be conceptualized as a social pollutant that, when ‘breathed’ into the body, may disrupt biological systems related to inflammation through mechanisms potentially overlapping with those altered by physical pollutants and toxicants.read more
Citations
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Journal ArticleDOI
Asthma: epidemiology, etiology and risk factors.
TL;DR: This paper evolved from the extensive literature review undertaken as part of a proposal for a longitudinal birth cohort study to examine risk factors for asthma.
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Stress and inflammation in exacerbations of asthma
Edith Chen,Gregory E. Miller +1 more
TL;DR: A model depicting the immunologic mechanisms by which psychological stress can exacerbate clinical symptoms in patients with asthma is outlined, and the importance of both social and physical exposures in the exacerbation of asthma symptoms is highlighted.
Journal ArticleDOI
Social Determinants: Taking the Social Context of Asthma Seriously
TL;DR: The central focus of the article is on the distal social variables that have given rise to unhealthy residential environments in which the risk factors for asthma and other diseases are clustered.
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Global strategy for the diagnosis and management of asthma in children 5 years and younger.
Søren Pedersen,Suzanne S. Hurd,Robert F. Lemanske,Allan B. Becker,Heather J. Zar,Peter D. Sly,Manuel Soto-Quiroz,Gary Wong,Eric D. Bateman +8 more
TL;DR: To aid in the diagnosis of asthma in young children, a symptoms‐only descriptive approach that includes the definition of various wheezing phenotypes has been recommended.
Journal ArticleDOI
Socioeconomic status and inflammatory processes in childhood asthma: the role of psychological stress.
Edith Chen,Margaret D. Hanson,Laurel Q. Paterson,Melissa Joy Griffin,Hope A. Walker,Gregory E. Miller +5 more
TL;DR: In this paper, a psychobiological explanation for the epidemiologic relationship between low socioeconomic status (SES) and poor childhood asthma outcomes was found in children with asthma, particularly among lower SES children.
References
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Protective and Damaging Effects of Stress Mediators
TL;DR: The long-term effect of the physiologic response to stress is reviewed, which I refer to as allostatic load, which is the ability to achieve stability through change.
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The inflammatory reflex
TL;DR: The discovery that cholinergic neurons inhibit acute inflammation has qualitatively expanded understanding of how the nervous system modulates immune responses, and the opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems.
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The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
TL;DR: Celsus described four of the five cardinal signs of inflammation 2000 years ago, and Eustachio discovered the adrenal glands almost 500 years ago; but not until 1936 did Selye note that in rats exposed to stressors, the adrenAL glands were enlarged, and the thymus and lymph nodes shrunken.
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Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
TL;DR: Gut microflora might be a hitherto unexplored source of natural immunomodulators and probiotics, for prevention of atopic disease in children at high risk.
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Pulmonary effects of inhaled ultrafine particles.
TL;DR: The hypothesis that ultrafine particles are causally involved in adverse responses seen in sensitive humans is based on several studies summarized in this brief review, and the studies performed so far support the ultrafine particle hypothesis.