The Inhibition Effects of Eugenol and Pulegone on Stenotrophomonas maltophilia: an Opportunistic Pathogen
Tuba Baygar
- Vol. 16, Iss: 1, pp 23-29
TLDR
According to the biological activity results, it can be concluded that these natural agents may be potentially used for veterinary sciences, food industry or pharmaceutical applications that aim to manage S. maltophilia biofilm.Abstract:
Aerobic, non-fermentative and Gram-negative Stenotrophomonas maltophilia is a multidrug-resistant bacilli that is known to be pathogen for human and animals. S. maltophilia has been isolated from different animal species and also found in a variety of environments including soil, water, and plants. S. maltophilia , which has the ability to form biofilms on surfaces that cause environmental problems, is resistant to many antibiotic classes such as cephalosporins, carbapenems, and aminoglycosides. Here in this study, its aimed to determine the inhibition activities of natural phenolic compounds eugenol and pulegone against S. maltophilia MU69. Antibacterial activities of eugenol and pulegone were initially determined by disc diffusion method. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were also determined by tube dilution assay. Antibiofilm activities of the compounds were investigated by crystal violet staining and also monitorized using Scanning Electron Microscopy (SEM). Zone of inhibition measurements were found to be 39 mm and 28 mm for eugenol and pulegone, respectively. MIC and MBC values were found to be 3.12 mg/mL for eugenol while these were 2.5 mg/mL and 5 mg/mL for pulegone, respectively. The highest antibiofilm activity was found to be 56.30±0.45% for MIC of eugenol. To our knowledge, this is the first report of the antibacterial and antibiofilm activity of eugenol and pulegone against S. maltophilia . According to the biological activity results, it can be concluded that these natural agents may be potentially used for veterinary sciences, food industry or pharmaceutical applications that aim to manage S. maltophilia biofilm.read more
Citations
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Antibacterial interactions of pulegone and 1,8‐cineole with monolaurin ornisin against Staphylococcus aureus
Ali Akbar Farhanghi,Javad Aliakbarlu,Hossein Tajik,Negar Mortazavi,Leila Manafi,Ghader Jalilzadeh-Amin +5 more
TL;DR: In this paper , the antibacterial interactions of 1,8-cineole and nisin with monolaurin ornisin against Staphylococcus aureus were investigated.
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Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats
Waqas Younis,Muhammad Nasir Hayat Malik,Alamgeer,Shah Jahan,Arquimedes Gasparotto Junior,Asifa Bashir +5 more
TL;DR: In this article , the authors evaluated the effect of pulegone's anti-hypertensive and vasoprotective activity in L-NAME-induced hypertensive rats using an invasive method.
References
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Journal ArticleDOI
Mechanisms of biofilm resistance to antimicrobial agents
Thien-Fah Mah,George A. O'Toole +1 more
TL;DR: Owing to the heterogeneous nature of the biofilm, it is likely that there are multiple resistance mechanisms at work within a single community.
Journal ArticleDOI
Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen
TL;DR: This review summarizes the current literature and presents S. maltophilia as an organism with various molecular mechanisms used for colonization and infection as an emerging multidrug-resistant global opportunistic pathogen.
Reference EntryDOI
Growing and analyzing static biofilms
TL;DR: In this article, the early stages of biofilm formation are examined using static biofilm assays, which are suitable for either small or relatively large-scale studies and can be used individually or in combination for the study of biofilms.
Journal ArticleDOI
Essential oils in combination and their antimicrobial properties.
TL;DR: An overview on the antimicrobial efficacy of combinations of EOs and their isolated components is provided, taking advantage of their synergistic and additive effects.
Journal ArticleDOI
Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane
TL;DR: The results suggest that the antibacterial activity of eugenol against Salmonella typhi is due to the interaction of e Eugenol on bacterial cell membrane.