The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks.
Nicolò Patroniti,Alberto Zangrillo,Federico Pappalardo,Adriano Peris,Giovanni Cianchi,Antonio Braschi,Giorgio Antonio Iotti,Antonio Arcadipane,Giovanna Panarello,V. Marco Ranieri,Pierpaolo Terragni,Massimo Antonelli,Luciano Gattinoni,Fabrizio Oleari,Antonio Pesenti +14 more
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TLDR
A network organization based on preemptive patient centralization allowed a high survival rate and provided effective and safe referral of patients with severe H1N1-suspected ARDS.Abstract:
Purpose
In view of the expected 2009 influenza A(H1N1) pandemic, the Italian Health Authorities set up a national referral network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS). We describe the organization and results of the network, known as ECMOnet.read more
Citations
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Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response.
TL;DR: An emergency task force was formed by the Government of Lombardy and local health authorities to lead the response to the outbreak and a forecast of estimated ICU demand over the coming weeks is provided.
Journal ArticleDOI
Extracorporeal Membrane Oxygenation for ARDS in Adults
Daniel Brodie,Matthew Bacchetta +1 more
TL;DR: A 41-year-old woman presents with severe community-acquired pneumococcal pneumonia, and chest radiography reveals diffuse bilateral infiltrates, and hypoxemic respiratory failure develops despite appropriate antibiotic therapy.
Journal ArticleDOI
Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis.
Tài Pham,Alain Combes,Hadrien Rozé,Sylvie Chevret,Alain Mercat,Antoine Roch,Bruno Mourvillier,Claire Ara-Somohano,Olivier Bastien,Elie Zogheib,Marc Clavel,Adrien Constan,Jean-Christophe M. Richard,Christian Brun-Buisson,Laurent Brochard +14 more
TL;DR: Under ECMO, an ultraprotective ventilation strategy minimizing plateau pressure may be required to improve outcome, and when patients with severe influenza A(H1N1)-related ARDS treated with ECMO were compared with conventionally treated patients, no difference in mortality rates existed.
Journal ArticleDOI
Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases.
Kollengode Ramanathan,David Antognini,Alain Combes,Matthew L. Paden,Bishoy Zakhary,Mark Ogino,Graeme MacLaren,Daniel Brodie,Kiran Shekar +8 more
TL;DR: ECMO preparedness for the COVID-19 pandemic is important in view of the high transmission rate of the virus and respiratory-related mortality and ensuring that systems enable safe and coordinated movement of critically ill patients, staff, and equipment is important to improve ECMO access.
Journal ArticleDOI
The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome
Matthieu Schmidt,Elie Zogheib,Hadrien Rozé,Xavier Repessé,Guillaume Lebreton,Charles-Edouard Luyt,Jean-Louis Trouillet,Nicolas Bréchot,Ania Nieszkowska,Hervé Dupont,Alexandre Ouattara,Pascal Leprince,Jean Chastre,Alain Combes +13 more
TL;DR: The PRESERVE score might help ICU physicians select appropriate candidates for ECMO among severe ARDS patients and future studies should also focus on physical and psychosocial rehabilitation that could lead to improved HRQL in this population.
References
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Journal ArticleDOI
The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination
Gordon R. Bernard,Antonio Artigas,Kenneth L. Brigham,J. Carlet,K. Falke,L. Hudson,M. Lamy,J. R. LeGall,Alan H. Morris,Roger G. Spragg +9 more
TL;DR: The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality, and financial cost.
Journal ArticleDOI
Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial.
Giles J. Peek,Miranda Mugford,Ravindranath Tiruvoipati,Andrew Wilson,Elizabeth Allen,Mariamma M. Thalanany,Clare Hibbert,Ann Truesdale,Felicity Clemens,Nicola J. Cooper,Richard K. Firmin,Diana Elbourne +11 more
TL;DR: Transfer of adult patients with severe but potentially reversible respiratory failure, whose Murray score exceeds 3.0 or who have a pH of less than 7.20 on optimum conventional management, to a centre with an ECMO-based management protocol is recommended to significantly improve survival without severe disability.
Journal ArticleDOI
Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009.
Seema Jain,Laurie Kamimoto,Anna M. Bramley,Ann Schmitz,Stephen R. Benoit,Janice K. Louie,David E. Sugerman,Jean K Druckenmiller,Kathleen A. Ritger,Rashmi Chugh,Supriya Jasuja,Meredith Deutscher,Sanny Chen,John D Walker,Jeffrey S. Duchin,Susan M. Lett,Susan Soliva,Eden V. Wells,David L. Swerdlow,David L. Swerdlow,Timothy M. Uyeki,Anthony E. Fiore,Sonja J. Olsen,Alicia M. Fry,Carolyn B. Bridges,Lyn Finelli +25 more
TL;DR: Data suggest that the use of antiviral drugs was beneficial in hospitalized patients, especially when such therapy was initiated early, and patients seemed to benefit from antiviral therapy.
Journal ArticleDOI
Extracorporeal membrane oxygenation for 2009 Influenza A (H1N1) Acute Respiratory Distress Syndrome
Andrew Davies,Daryl A Jones,Michael Bailey,John Beca,Rinaldo Bellomo,Nikki Blackwell,Paul Forrest,David Gattas,Emily Granger,Robert Herkes,Andrew Jackson,Shay McGuinness,Priya Nair,Vincent Pellegrino,Ville Pettilä,Brian T Plunkett,R. Pye,Paul J. Torzillo,Steven A R Webb,Michael K. Wilson,Marc Ziegenfuss +20 more
TL;DR: The characteristics of all patients with 2009 influenza A(H1N1)-associated ARDS treated with ECMO are described and clinical features, degree of pulmonary dysfunction, technical characteristics, duration of ECMO, complications, and survival are reported.
Journal ArticleDOI
Critically ill patients with 2009 influenza A(H1N1) infection in Canada.
Anand Kumar,Ryan Zarychanski,Ruxandra Pinto,Deborah J. Cook,John C. Marshall,Jacques Lacroix,Tom Stelfox,Sean M. Bagshaw,Karen Choong,Francois Lamontagne,Alexis F. Turgeon,Stephen E. Lapinsky,Stéphane P. Ahern,Orla Smith,Faisal Siddiqui,Philippe Jouvet,Kosar Khwaja,Lauralyn McIntyre,Kusum Menon,Jamie Hutchison,David Hornstein,Ari R. Joffe,François Lauzier,Jeffrey M. Singh,Tim Karachi,Kim Wiebe,Kendiss Olafson,Clare D. Ramsey,Sat Sharma,Peter Dodek,Maureen O. Meade,Richard I. Hall,Robert A. Fowler +32 more
TL;DR: Critical illness due to 2009 influenza A(H1N1) in Canada occurred rapidly after hospital admission, often in young adults, and was associated with severe hypoxemia, multisystem organ failure, a requirement for prolonged mechanical ventilation, and the frequent use of rescue therapies.
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