The Limbal Niche and Regenerative Strategies
Sohil Amin,Elmira Jalilian,Eitan Katz,Charlie Frank,Ghasem Yazdanpanah,Victor H. Guaiquil,Mark I. Rosenblatt,Ali R. Djalilian +7 more
- Vol. 5, Iss: 4, pp 43
TLDR
In this article, a review outlines the current understanding of the limbal niche, its pathology and the emerging approaches targeted at restoring the limbo-nomenclature and accelerating corneal regeneration.Abstract:
The protective function and transparency provided by the corneal epithelium are dependent on and maintained by the regenerative capacity of limbal epithelial stem cells (LESCs). These LESCs are supported by the limbal niche, a specialized microenvironment consisting of cellular and non-cellular components. Disruption of the limbal niche, primarily from injuries or inflammatory processes, can negatively impact the regenerative ability of LESCs. Limbal stem cell deficiency (LSCD) directly hampers the regenerative ability of the corneal epithelium and allows the conjunctival epithelium to invade the cornea, which results in severe visual impairment. Treatment involves restoring the LESC population and functionality; however, few clinically practiced therapies currently exist. This review outlines the current understanding of the limbal niche, its pathology and the emerging approaches targeted at restoring the limbal niche. Most emerging approaches are in developmental phases but show promise for treating LSCD and accelerating corneal regeneration. Specifically, we examine cell-based therapies, bio-active extracellular matrices and soluble factor therapies in considerable depth.read more
Citations
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Collagen as a Biomaterial for Skin and Corneal Wound Healing
TL;DR: A review of the effect of several current collagen implants on the stimulation of corneal and skin wound healing can be found in this paper , where the authors discuss the effects of these implants on wound ECM deposition.
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Bone marrow mesenchymal stromal cells in a 3D system produce higher concentration of extracellular vesicles (EVs) with increased complexity and enhanced neuronal growth properties
Elmira Jalilian,Hamed Massoumi,Bianca Bigit,Sohil Amin,Eitan Katz,Victor H. Guaiquil,Khandaker N. Anwar,Peiman Hematti,Mark I. Rosenblatt,Ali R. Djalilian +9 more
TL;DR: In this article , the authors investigated the potential differences in neuro-regenerative properties of mesenchymal stromal cells (MSCs) derived in 2D versus 3D culture systems.
Journal ArticleDOI
Bone marrow mesenchymal stromal cells in a 3D system produce higher concentration of extracellular vesicles (EVs) with increased complexity and enhanced neuronal growth properties
Elmira Jalilian,Hamed Massoumi,Bianca Bigit,Sohil Amin,Eitan Katz,Victor H. Guaiquil,Khandaker N. Anwar,Peiman Hematti,Mark I. Rosenblatt,Ali R. Djalilian +9 more
TL;DR: In this article , the authors investigated the potential differences in neuro-regenerative properties of mesenchymal stromal cells (MSCs) derived in 2D versus 3D culture systems.
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Combined Therapy Using Human Corneal Stromal Stem Cells and Quiescent Keratocytes to Prevent Corneal Scarring after Injury
Vishal Jhanji,Mithun Santra,Andri K. Riau,Moira L. Geary,Tianbing Yang,Elizabeth Rubin,Nur Zahirah Binte M Yusoff,Deepinder K. Dhaliwal,Jodhbir S. Mehta,Gary Hin-Fai Yam +9 more
TL;DR: It is hypothesized that the immuno-regulatory nature of CSSC is effective to control tissue inflammation and delay the onset of fibrosis, and a subsequent intrastromal CSK treatment deposited collagens and stromal specific proteoglycans to recover a nativeStromal matrix.
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Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery
Mohammad Soleimani,Ahmad Masoumi,Bita Momenaei,Kasra Cheraqpour,Raghuram Koganti,A Chang,Mahmoud Ghassemi,Ali R. Djalilian +7 more
TL;DR: In this article , Mesenchymal stem cells (MSCs) are used for treating ocular surface disorders such as chemical or thermal burns, limbal stem cell deficiency, neurotrophic keratopathy, and infectious keratitis.
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