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Annette Becker
Researcher at Technische Universität Darmstadt
Publications - 14
Citations - 4593
Annette Becker is an academic researcher from Technische Universität Darmstadt. The author has contributed to research in topics: Heterochromatin & Chromatin. The author has an hindex of 11, co-authored 13 publications receiving 3665 citations. Previous affiliations of Annette Becker include Cornell University & Rockefeller University.
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Journal ArticleDOI
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Bruno Costa-Silva,Nicole M. Aiello,Allyson J. Ocean,Swarnima Singh,Haiying Zhang,Basant Kumar Thakur,Basant Kumar Thakur,Annette Becker,Ayuko Hoshino,Milica Tesic Mark,Henrik Molina,Jenny Xiang,Tuo Zhang,Till Martin Theilen,Guillermo García-Santos,Caitlin Williams,Yonathan Ararso,Yujie Huang,Gonçalo Rodrigues,Tang-Long Shen,Knut Jørgen Labori,Inger Marie Bowitz Lothe,Elin H. Kure,Jonathan M. Hernandez,Alexandre Doussot,Saya H. Ebbesen,Paul M. Grandgenett,Michael A. Hollingsworth,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Robert E. Schwartz,Irina Matei,Héctor Peinado,Ben Z. Stanger,Jacqueline Bromberg,David Lyden,David Lyden +38 more
TL;DR: It is shown that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden and suggests that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.
Journal ArticleDOI
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Annette Becker,Basant Kumar Thakur,Joshua Mitchell Weiss,Han Sang Kim,Han Sang Kim,Héctor Peinado,David Lyden +6 more
TL;DR: Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
PatentDOI
Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
David Lyden,Hector Peinado Selgas,Haiying Zhang,Basant Kumar Thakur,Annette Becker,Jacqueline Bromberg +5 more
TL;DR: In this paper, the authors present methods of prognosing, treating, or managing treatment of cancer in a subject, which involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes and isolating the double-stranded DNA from within the exosome.
Journal ArticleDOI
MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation
Noopur Agarwal,Tanja Hardt,Alessandro Brero,Danny Nowak,Ulrich Rothbauer,Annette Becker,Heinrich Leonhardt,M. Cristina Cardoso +7 more
TL;DR: It is proposed that this dynamic interaction of HP1 and MeCP2 increases their concentration at heterochromatin linking two major gene silencing pathways to stabilize transcriptional repression during differentiation.
Journal ArticleDOI
MeCP2 Rett mutations affect large scale chromatin organization
Noopur Agarwal,Annette Becker,K. Laurence Jost,K. Laurence Jost,Sebastian Haase,Basant Kumar Thakur,Alessandro Brero,Tanja Hardt,Shinichi Kudo,Heinrich Leonhardt,M. Cristina Cardoso,M. Cristina Cardoso +11 more
TL;DR: It is proposed that different interactions of MeCP2 with methyl cytosines, DNA and likely other heterochromatin proteins are required for Me CP2 function and their dysfunction lead to Rett syndrome.