Journal ArticleDOI
The nature of retinoblastoma. II. Photoreceptor differentiation: an electron microscopic study.
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In this histopathologic study of retinoblastomas exhibiting an unusual form of dif ferentiation, it seemed apparent that these tumors were producing structures resem bling elements of the photoreceptor cell.About:
This article is published in American Journal of Ophthalmology.The article was published on 1970-03-01. It has received 129 citations till now. The article focuses on the topics: Photoreceptor cell.read more
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Journal ArticleDOI
Newly established human retinoblastoma cell lines exhibit an "immortalized" but not an invasive phenotype in vitro.
Sabine Griegel,Chen Hong,Roland Frötschl,Dieter F. Hülser,Valerie Greger,Bernhard Horsthemke,Manfred F. Rajewsky +6 more
TL;DR: It was found that RB tumors consist of phenotypically heterogeneous cell subpopulations with varying nutrient requirements and differentiation potential in vitro and all cell lines showed the typical characteristics of established (immortalized) cells.
Journal ArticleDOI
Immunocytochemistry of neuronal and glial markers in retinoblastoma
G. Terenghi,J.M. Polak,J. Ballesta,Domenico Cocchia,Fabrizio Michetti,Doris Dahl,Paul J. Marangos,A. Garner +7 more
TL;DR: The results of this study indicate that the retinoblastoma may arise from a pluripotential primitive cell partially retaining neuronal and glial characteristics.
Journal Article
The Wilms' tumor suppressor Wt1 is associated with the differentiation of retinoblastoma cells.
Nicole Wagner,Kay-Dietrich Wagner,Gunnar Schley,Sarah E. Coupland,Heinrich Heimann,Rosemarie Grantyn,Holger Scholz +6 more
TL;DR: A role for Wt1 in the differentiation of retinoblastoma cells is suggested, which may reflect the potential of these tumors to initiate the early steps of neuronal differentiation.
Journal ArticleDOI
Glycine Uptake by Cultured Human Y79 Retinoblastoma Cells: Effect of Changes in Phospholipid Fatty Acid Unsaturation
TL;DR: One of the effects of the high polyunsaturated fatty acid content normally present in neural cell membranes may be a modulation of thehigh‐affinity transport system so that it functions more efficiently in regulating glycine uptake.
Journal ArticleDOI
Histopathologic Grading of Anaplasia in Retinoblastoma
Pia R. Mendoza,Charles S. Specht,G. Baker Hubbard,Jill R. Wells,Michael J. Lynn,Qing Zhang,Jun Kong,Hans E. Grossniklaus +7 more
TL;DR: Grading of anaplasia may be a useful adjunct to standard histopathologic criteria in identifying retinoblastoma patients who do not have high-risk histologic features but still have an increased risk of metastasis and may need adjuvant therapy.
References
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Book ChapterDOI
Cilia and Flagella
TL;DR: Cilia are motile, hairlike appendages on the free surface of cells that play an important role in such diverse physiological processes as locomotion, alimentation, circulation, respiration, reproduction, and sensory reception.
Journal ArticleDOI
The Nature of Retinoblastoma. I. Photoreceptor Differentiation: A Clinical and Histopathologic Study
Journal Article
Applications of histochemical methods for the demonstration of acid mucopolysaccharides to ophthalmic pathology.
Journal ArticleDOI
Beiträge zur Histogenese und Histologie der Netzhaut, des Pigmentepithels und des Sehnerven
TL;DR: In this paper, the authors present an overview of the evolution of the Retinazelle and its relationship with the rest of the body of work in the field of physicologischen excavations.