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Open AccessJournal ArticleDOI

The next 30 years--will the progress continue?

R S Ross
- 01 Jul 1980 - 
- Vol. 62, Iss: 1, pp 1-7
TLDR
If progress is to continue, a constant supply of bright young men and women must enter careers in basic research and clinical investigation and action must be taken to assure the continuation of the research enterprise that has been respoinsible for the progress of the last 30 years.
Abstract
Spectacular progress has occurred in cardiology during the past 30 years. The major advances that have resulted in the better methods of diagnosis and treatment of patients stem from basic research that was often unrelated to the ultimate practical application. An excellent example of this process is the evolution of the concept of ,B blockade from the pharmacology laboratory to practical clinical application in a variety of conditions. The sequence of discovery, translation, and application depends on many factors, but most important is the trained, dedicated investigator. If progress is to continue, a constant supply of bright young men and women must enter careers in basic research and clinical investigation. Recent studies show that the pool of biomedical scientists is shrinkiing and fewer young people are selecting research careers; thus, the process upon which our future depends is threatened. The socioeconomic forces that tend to turn the potential stars of the future away from research careers have been identified, and they must be counterbalanced. For 30 years. the American Heart Association has been a leader in the conquest of heart disease through research. The faith of the Association in research must be reaffirmed. The relationship of today's basic research to the good medical care of the future must be explained to the people and to their elected representatives in words that they understand. Action must be taken to assure the continuation of the research enterprise that has been respoinsible for the progress of the last 30 years.

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Citations
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Practice Standards for Electrocardiographic Monitoring in Hospital Settings An American Heart Association Scientific Statement From the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young

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Aspirin and the Stomach

TL;DR: Endoscopic studies linking the extent and degree of acute mucosal injury to various nonsteroidal anti-inflammatory drugs have little or no value in predicting the frequency or severity of chronic gastric ulcer or gastrointestinal bleeding.
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Return of left ventricular function after reperfusion in patients with myocardial infarction: importance of subtotal stenoses or intact collaterals.

TL;DR: Among patients with acute myocardial infarction undergoing emergency coronary arteriography at a mean of 7 hr after onset of symptoms, improvement in global ejection fraction is unlikely to occur even after a successful early reperfusion intervention in the absence of preserved flow to the infarct area.
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The effect of intraaortic balloon counterpulsation on regional myocardial blood flow and oxygen consumption in the presence of coronary artery stenosis in patients with unstable angina.

TL;DR: Relief of angina during IABP could not be ascribed to an increase in regional coronary blood flow, and reduction of myocardial oxygen consumption is the most likely mechanism by which IABB relieves myocardia ischemia in patients with unstable angina pectoris.
References
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TL;DR: The physician-investigator as an endangered species and with the future of clinical research are dealt with.
Journal ArticleDOI

Scientific basis for the support of biomedical science

Julius H. Comroe, +1 more
- 09 Apr 1976 - 
TL;DR: This project has only one goal: to demonstrate that objective, scientific techniques can be used to design and justify a national biomedical research policy.
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TL;DR: The greater effectiveness of prostaglandins on the anoxic ductus suggests a role for these compounds in the regulation of the vessel tone during fetal life.
Journal ArticleDOI

Medical manipulation of the ductus arteriosus

TL;DR: Prostaglandin E-1 was infused into two children with cyanotic congenital heart-disease where patency of the ductus arteriosus was necessary to maintain arterial oxygen saturation, and administration of the non-specific antagonist of prostaglandsin synthesis, indomethacin, was associated with a fall in arterial saturation.
Journal ArticleDOI

On the action of prostaglandin e1 and prostaglandins from brain on the isolated rat stomach

TL;DR: Prostaglandins were taken up by the tissue or produced a persistent change when added under anoxic conditions, but were unable to act unless oxygen was present, while drugs that stimulated sympathetic receptors were inhibitory.
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