Journal ArticleDOI
The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions.
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TLDR
In this paper , a review of the relationship between PI3K/AKT signaling pathway and factors contributing to initiation and development of various cancers is presented, and therapeutic interventions regulating this signaling pathway have been summarized.About:
This article is published in Experimental and Molecular Pathology.The article was published on 2022-05-01. It has received 11 citations till now. The article focuses on the topics: Medicine & PI3K/AKT/mTOR pathway.read more
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Ropivacaine represses the ovarian cancer cell stemness and facilitates cell ferroptosis through inactivating the PI3K/AKT signaling pathway
TL;DR: Ropivacaine restrained ovarian cancer cell stemness and accelerated cell ferroptosis by inactivating PI3K/AKT signaling pathway and had a protective function in ovarian cancer.
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Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
TL;DR: In this paper , the main signaling pathways and potential targets of TCM and its active ingredients in the treatment of colorectal cancer were systematically summarized, providing a theoretical basis for treating CRC with TCM.
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Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer
TL;DR: THD synergizes with DDP to exert suppressive effects on cervical cancer cell lines and inactivated the PI3K/AKT and JAK1/STAT3 pathways, suggesting that the combined use of THD and DPP may have potential in the treatment of cervical cancer.
Journal ArticleDOI
Nonsense-Mediated mRNA Decay as a Mediator of Tumorigenesis
TL;DR: In this paper , the authors discuss how nonsense-mediated mRNA decay (NMD) is regulated as a critical mediator of oncogenesis to promote the development and progression of tumor cells.
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Anti-tumor effects of low-dose metronomic vinorelbine in combination with alpelisib in breast cancer cells
S. Krajnak,K Anic,Anne-Sophie Heimes,Amelie Loewe,Marc Schmitz,Marco Johannes Battista,Annette Hasenburg,Walburgis Brenner +7 more
TL;DR: In this article, the anti-tumor activity of low-dose vinorelbine (VRL) combined with alpelisib, an α-selective PI3K inhibitor and degrader, in breast cancer (BC) cells was investigated.
References
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Journal ArticleDOI
Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
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PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Jing Li,Clifford Yen,Danny Liaw,Katrina Podsypanina,Shikha Bose,Steven I. Wang,Janusz Puc,Christa Miliaresis,Linda Rodgers,Richard W. McCombie,Sandra H. Bigner,Beppino C. Giovanella,Michael Ittmann,B. Tycko,Hanina Hibshoosh,Michael Wigler,Ramon Parsons +16 more
TL;DR: The PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin, a protein that interacts with actin filaments at focal adhesions as discussed by the authors.
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Mdm2 promotes the rapid degradation of p53
TL;DR: It is proposed that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of the p53 signal.
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Regulation of p53 stability by Mdm2
TL;DR: It is shown that interaction with Mdm2 can also result in a large reduction in p53 protein levels through enhanced proteasome-dependent degradation, which may contribute to the maintenance of low p53 concentrations in normal cells.
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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
Dario R. Alessi,Stephen R. James,C. Peter Downes,Andrew B. Holmes,Piers R. J. Gaffney,Colin B. Reese,Philip Cohen +6 more
TL;DR: In this paper, a protein kinase that phosphorylates PKB α at Thr308 and increases its activity over 30-fold was found to play a key role in mediating the activation of PKB by insulin and growth factors.