Showing papers in "Experimental and Molecular Pathology in 2022"

TL;DR: In this paper , a review of the relationship between PI3K/AKT signaling pathway and factors contributing to initiation and development of various cancers is presented, and therapeutic interventions regulating this signaling pathway have been summarized.

TL;DR: In this paper, a rational analysis of the multifaceted therapeutic effects and underlying mechanisms of isotype-specific peroxisome proliferator-activated receptors (PPARs) is presented.

TL;DR: In this article , aberrant DNA methylation accumulation affects self-renewal, differentiation, multidrug-resistant, and metastasis processes in cancer stem cells (CSCs).

TL;DR: In this article , a rational analysis of the multifaceted therapeutic effects and underlying mechanisms of isotype-specific peroxisome proliferator-activated receptors (PPARs) is presented.

TL;DR: In this paper , the authors compared the cell cycle and proliferation of acute wound fibroblasts (AWFs) and chronic wound fibrosomes (CWFs) based on differential expression of fibroblast specific markers such as Vimentin and Alpha Smooth Muscle Actin (α-SMA) and found that AWFs showed higher distributions in G0/G1 (67.43% vs 62.16%), S phase (22.61% vs 8.51%) compared to CWFs.

TL;DR: Zhang et al. as mentioned in this paper showed that Sirt2 positively regulated skeletal muscle regeneration after muscle injury by regulating transcriptional expression involved in myogenesis, cell cycle, and anabolic and catabolic signaling.

TL;DR: In this article , the antihyperglycemic properties of arginase inhibition via L-norvaline and its combination with NOS substrate supplementation (via L-arginine) were studied.

TL;DR: In this article , the role of TGF-β1 in the progression of non-Alcoholic Fatty Liver Disease (NAFLD) is discussed. But the authors focus on the effect of the TGFβ1 signaling pathway on liver lipid overload.

TL;DR: In this paper , the effect of dapsone on bleomycin-induced IPF in adult male Wistar rats due to its anti-inflammatory and anti-oxidative stress effects was investigated.

TL;DR: The role of miR-335-5p in esophageal cancer by expression and functional studies was evaluated using MTT assay, cell cycle analysis, colony formation assay, scratch assay, matrigel invasion, and migration assay as discussed by the authors .

TL;DR: In this article , the authors used the Cancer Genome Atlas lung adenocarcinoma (TCGA_LUAD) cohort to describe the molecular data associated to tumor grading.

TL;DR: An overview of the PI3K-AKT signaling pathway and the relationship between this pathway and Parkinson's disease is provided in this paper , which provides an effective resource for the discovery of potential therapeutic drugs.

TL;DR: Tuszynski et al. as discussed by the authors found that GASP-1 promotes proliferation and invasion of the triple negative breast cancer cell line MDA-MB-231 and targeting GASPs for treatment of breast cancer is indicated.

TL;DR: In this paper , an unbiased in silico method was used to rank the yet to profiled long non-coding RNA (lncRNAs) in colorectal cancer.

TL;DR: Combined analysis of cytokeratin 7 (CK7) and CK20 is often used for assessing the origin of metastatic cancer as mentioned in this paper , and the diagnostic utility of CK7 and CK20, tissue microarrays containing 15,424 samples from 120 different tumor types and subtypes and 608 samples of 76 different normal tissue types were analyzed by immunohistochemistry.

TL;DR: In this paper , the expression patterns of PRAME and SOX17 were compared by immunohistochemistry in both pure and mixed GCT, and it was shown that PRAME is preferentially expressed in SEM or within the seminomatous component of mixed gCT with only focal variable expression in YST and CC.

TL;DR: In this paper , the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage, Professors C.S. Lieber and S.W. French, was discussed.

TL;DR: In this article , the authors examined the effect of miR-200c restoring on enhancing the BC cells' sensitivity to Doxorubicin through downregulating the MDR1 expression.

TL;DR: In this paper , the authors used single-nucleus RNA sequencing (snRNA-seq) to demonstrate the heterogeneity of macrophages associated with liver Mallory-Denk bodies (MDBs) formation in mice through single-cell resolution.

TL;DR: In this article , the authors investigated the mechanisms behind the protective effects of ranolazine on the heart and brain in Dox-treatment, and found that ranoline significantly improved the left ventricular (LV) function via attenuating cardiac injury.

TL;DR: In this paper , the authors found that phloretin induced autophagy in SH-SY5Y cells by decreasing p-AKT and p-mTOR levels in the AKT/mTOR pathway and increasing the activation of JNK, the phosphorylation of c-Jun and the expression of Beclin-1.

TL;DR: In this article , the authors evaluated the inhibition of cell growth by 17-trifluoromethyl phenyl trinor prostaglandin F2α with NK1 receptor in breast cancer cell lines and found that PGF2a has a high binding affinity towards NK1 Receptor from molecular docking studies.

TL;DR: In this paper , the authors report a patient who underwent hysterectomy due to a large leiomyoma and who was diagnosed with pulmonary tumors seven and nine years later.

TL;DR: In this paper , the authors assessed the fragmentation degree of 116 lung cancer FFPE DNA samples to calculate the amount of amplifiable input DNA used for library preparation, and showed that the size of the amplifiable DNA predicted library complexity better than the input measured in nanograms.

TL;DR: In this article , the authors showed that EPO either before or during ischemia, but not at reperfusion, exerted cardioprotection against I/R injury by attenuating mitochondrial dynamic imbalance, mitochondrial dysfunction, and apoptosis, leading to reduced infarct size and improved LV function.

TL;DR: In this article , a study was conducted to verify if iron supplementation could alleviate these perturbations, compared to doxorubicin, an anthracycline analog.

TL;DR: In this paper , the authors combined a small custom designed targeted expression panel with a commercial fusion transcript assay by which they were able to perform both a histological classification (transcribing the expression of the genes encoding TTF1, Napsin A, CK5/6, and the truncated P63 isoform ΔNp63 (p40) into either adenocarcinoma or squamous cell carcinoma) and an identification of fusion genes involving ALK, RET, and ROS1.

TL;DR: In this paper , a systemic induction of autophagy, via the target of rapamycin (PI3K/mTOR) inhibition, was proposed to prevent anal cancer development in human papillomavirus (HPV) mice.

TL;DR: The combination of Smac mimetic LCL-161 and TRAIL induces an irreversible change in phenotype, but not cell death, of luminal MCF-7 breast cancer cells as discussed by the authors .

TL;DR: In this paper , the authors investigated the utility of Matrix Metalloproteinases (MMPs) in mediating vascular permeability and plasma leakage following induction by the dengue virus.