Journal ArticleDOI
The protein kinases of budding yeast: six score and more.
Tony Hunter,Gregory D. Plowman +1 more
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TLDR
The completion of the budding yeast genome sequencing project has made it possible to determine not only the total number of genes, but also the exactnumber of genes of a particular type 1-3, so that the authors now know exactly how many protein kinases are encoded by the yeast genome.About:
This article is published in Trends in Biochemical Sciences.The article was published on 1997-01-01. It has received 490 citations till now. The article focuses on the topics: Cyclin-dependent kinase 1 & TAF4.read more
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The Protein Kinase Complement of the Human Genome
TL;DR: The protein kinase complement of the human genome is catalogued using public and proprietary genomic, complementary DNA, and expressed sequence tag sequences to provide a starting point for comprehensive analysis of protein phosphorylation in normal and disease states and a detailed view of the current state of human genome analysis through a focus on one large gene family.
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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Gray W. Pearson,Fred L. Robinson,Tara Beers Gibson,Bing E. Xu,Mahesh Karandikar,Kevin S. Berman,Melanie H. Cobb +6 more
TL;DR: Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted and particular emphasis is on ERK1/2.
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Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
TL;DR: All known MAPK module kinases from yeast to humans are defined, what is known about their regulation, defined MAPK substrates, and the function of MAPK in cell physiology are defined.
Journal ArticleDOI
Signaling--2000 and beyond.
TL;DR: The important findings in the history of signal transduction are adequately covered in many reviews, and I have therefore cited reviews that discuss the seminal papers.
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Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases.
TL;DR: The distribution pattern of four RLK subfamilies on Arabidopsis chromosomes indicates that the expansion of this gene family is partly a consequence of duplication and reshuffling of theArabidopsis genome and of the generation of tandem repeats.
References
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Journal ArticleDOI
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
Steven K. Hanks,Tony Hunter +1 more
TL;DR: The eukaryotic protein kinases make up a large superfamily of homologous proteins, and a classification scheme can be founded on a kinase domain phylogeny, which reveals families of enzymes that have related substrate specificities and modes of regulation.
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Hidden markov models in computational biology: applications to protein modeling
TL;DR: The results suggest the presence of an EF-hand calcium binding motif in a highly conserved and evolutionary preserved putative intracellular region of 155 residues in the alpha-1 subunit of L-type calcium channels which play an important role in excitation-contraction coupling.
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Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor
Francesc Posas,Susannah M. Wurgler-Murphy,Tatsuya Maeda,Elizabeth Witten,Tran C. Thai,Haruo Saito +5 more
TL;DR: It is proposed that the multistep phosphorelay mechanism is a universal signal transduction apparatus utilized both in prokaryotes and eukaryotes.
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Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
TL;DR: Two new mammalian MAPK relatives, JNK1 and p38, are identified, and the pathways which are responsible for their activation are identified.
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Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
Steven K. Hanks,Tony Hunter +1 more