Journal ArticleDOI
The role of cell adhesion in the synchronization and orientation of polarization in 8-cell mouse blastomeres
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Since polarization marks an important and early event in the process of cell diversification in the mouse embryo, it is concluded that the CDS provides an important component of the system by which the temporal and spatial elements of normal development are integrated.Abstract:
A detailed investigation into the activity of the homotypic, Ca2+-dependent cell-cell adhesion system (CDS) in the early mouse embryo has revealed its involvement in (i) the synchronizing of the time of polarization of 8-cell blastomeres, and (ii) the orienting of the axis of polarization. Since polarization marks an important and early event in the process of cell diversification in the mouse embryo, it is concluded that the CDS provides an important component of the system by which the temporal and spatial elements of normal development are integrated.read more
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The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.
TL;DR: It appears that each cadherin subclass has binding specificity and this molecular family is involved in selective cell-cell adhesion, indicating a crucial role in construction of tissues and the whole animal body.
Journal ArticleDOI
E-cadherin null mutant embryos fail to form a trophectoderm epithelium
TL;DR: The pivotal role of E-cadherin in one of the most basic morphogenetic events in the development of multicellular organisms, the biogenesis of an epithelium, is demonstrated.
Journal ArticleDOI
The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.
TL;DR: The role of the epithelial adhesion molecule uvomorulin seems to mediate an early adhesion event between epithelial cells that is a prerequisite for the assembly of all elements of the junctional complex.
Journal ArticleDOI
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse.
Janet Rossant,Patrick P.L. Tam +1 more
TL;DR: The investigation into lineage allocation and early asymmetries in the pre- and peri-implantation mouse embryo is gaining momentum and new insights have been gained into the cellular and molecular events that lead to the establishment of the three lineages of the blastocyst.
Journal ArticleDOI
Role of laminin a chain in the development of epithelial cell polarity
TL;DR: Since the fragments at the carboxy-terminal end contain parts of the A chain, it is suggested that the appearance of this chain is fundamental for initiation of cell polarity.
References
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Journal ArticleDOI
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more
TL;DR: A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described, which defines an embryonic stage-specific antigen.
Journal ArticleDOI
Activation of mammalian oocytes by intracellular injection of calcium.
TL;DR: It is reported here that parthenogenetic activation and subsequent normal development can be induced in mouse oocytes by injecting them with Ca2+.
Journal ArticleDOI
The foundation of two distinct cell lineages within the mouse morula
Martin H. Johnson,C. A. Ziomek +1 more
TL;DR: It is suggested that the foundation of the trophectoderm and inner cell mass lineages lineages may occur by a process of differential inheritance, which supports the recently proposed polarization hypothesis.
Journal ArticleDOI
Ultrastructural localization of lectin-binding sites on the zonae pellucidae and plasma membranes of mammalian eggs.
TL;DR: The asymmetric density of RCAI receptors across the zona was confirmed by ferritin- RCAI and fluorescein-RCAI labeling of mechanically isolated zonae pellucidae, indicating that the RCAi-binding sites are more densely distributed in the exterior zona regions.
Journal ArticleDOI
A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos
TL;DR: Fab fragments of rabbit anti-embryonal carcinoma cells IgG dramatically perturb cell-cell interactions between embryonal carcinomas cells and between early mouse embryo blastomeres to prevent compaction of preimplantation embryos.
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