The Role of X-Chromosome Inactivation during Spermatogenesis
TLDR
X-chromosome inactivation during spermatogenesis is proposed as the ideal system for studies of genetic control at the chromosomal level.Abstract:
Inactivation of the single X chromosome in the primary spermatocytes of species with heterogametic males is postulated as a basic control mechanism on the chromosomal level that is required for normal spermatogenesis. This view is supported by (a) cytological observations of X-chromosome allocycly in the primary spermatocytes of all male-heterogametic organisms that were adequately examined, (b) autoradiographic evidence of early cessation of transcription by the X chromosome in the mouse and three species of grasshopper, and (c) the male sterility of animals with certain X-chromosome rearrangements that cannot be attributed to misfunction of specific genes. X-chromosome inactivation during spermatogenesis is proposed as the ideal system for studies of genetic control at the chromosomal level.read more
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Paucity of Genes on the Drosophila X-Chromosome Showing Male-Biased Expression
Michael Parisi,Rachel Nuttall,Daniel Q. Naiman,Gerard G. Bouffard,James D. Malley,Justen Andrews,Scott Eastman,Brian Oliver +7 more
TL;DR: Using comparative genomics, it is found that the X chromosome is a disfavored location for genes selectively expressed in males in Drosophila melanogaster and these same X-chromosome genes are exceptionally poorly conserved in the mosquito Anopheles gambiae.
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