Journal ArticleDOI
The shape of lipid molecules and monolayer membrane fusion
L.V. Chernomordik,Michael M. Kozlov,G.B. Melikyan,I.G. Abidor,Vladislav S. Markin,Yu.A. Chizmadzhev +5 more
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TLDR
In this article, a theoretical model of the monolayer fusion is suggested to explain the results, assuming that the structural reorganization underlying the process involves the formation of a stalk between bilayers as a result of local bending of the interacting monolayers.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1985-02-14. It has received 213 citations till now. The article focuses on the topics: Monolayer & Bilayer.read more
Citations
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Coarse grained model for semiquantitative lipid simulations
TL;DR: In this article, a coarse-grained (CG) model for lipid and surfactant systems is presented, where only a small number of coarse grained atom types interact using a few discrete levels of interaction.
Journal ArticleDOI
Mechanics of membrane fusion.
TL;DR: The conserved fusion-through-hemifusion pathway of merger between biological membranes is discussed and it is proposed that the entire progression, from the close juxtaposition of membrane bilayers to the expansion of a fusion pore, is controlled by protein-generated membrane stresses.
Journal ArticleDOI
Reversible electrical breakdown of lipid bilayers: formation and evolution of pores.
TL;DR: The mechanism of reversible electric breakdown of lipid membranes is studied and hydrophilic pores of an effective radius of 0.6 up to more than 1 nm are formed, which account for the membrane conductivity increase observed.
Journal ArticleDOI
Lipids in biological membrane fusion.
TL;DR: The results reviewed suggest that membrane fusion in diverse biological fusion reactions involves formation of some specific intermediates: stalks and pores, and suggest a specific geometry to bent fusion intermediates (stalks and pores) and imply a contribution by lipids to the energy of these intermediates.
Journal ArticleDOI
Stalk model of membrane fusion: solution of energy crisis.
TL;DR: This work suggests a new structure for the fusion stalk, which resolves the energy crisis of the model and provides the experimentally testable predictions for the structural features of the stalk intermediates.
References
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Journal ArticleDOI
Elastic Properties of Lipid Bilayers: Theory and Possible Experiments
TL;DR: A theory of the elasticity of lipid bilayers is proposed and it is argued that in the case of vesicles (= closed bilayer films) the only elasticity controlling nonspherical shapes is that of curvature.
Journal ArticleDOI
Lipid polymorphism and the functional roles of lipids in biological membranes.
Pieter R. Cullis,B. de Kruijff +1 more
TL;DR: The possible functional roles of lipids are reviewed in terms of previous models such as the fluid mosaic model of Singer and Nicolson or the earlier unit membrane model so that the requirement for an alternative approach becomes apparent.
Journal ArticleDOI
Physical principles of membrane organization.
TL;DR: An understanding of the physical principles that govern the molecular organization of membranes is essential for an understanding of their physiological roles since structure and function are much more interdependent in membranes than in, say, simple chemical reactions in solution.
Journal ArticleDOI
Theory of self-assembly of lipid bilayers and vesicles
TL;DR: A unified theory is developed that explains the formation of bilayers and vesicles and accounts quantitatively for many of their physical properties: properties including vesicle size distributions and bilayer elasticity emerge from a unified theory that links thermodynamics, interaction free energy, and molecular geometry.
Journal ArticleDOI
246 - Electric breakdown of bilayer lipid membranes I. The main experimental facts and their qualitative discussion
I.G. Abiror,V.B. Arakelyan,L.V. Chernomordik,Yu.A. Chizmadzhev,V. F. Pastushenko,M.R. Tarasevich +5 more
TL;DR: In this paper, a qualitative interpretation of the breakdown phenomenon is proposed, which is based upon the concept of structural defects of the type of throughgoing pores, whose development is favored by the electric field.
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