Journal ArticleDOI
The Structural Factor of Hypertension Large and Small Artery Alterations
TLDR
An integrated pathophysiological approach is proposed to better understand how the cross-talk between large and small artery changes interacts in pressure wave transmission, exaggerates cardiac, brain and kidney damage, and lead to cardiovascular and renal complications.Abstract:
Pathophysiological studies have extensively investigated the structural factor in hypertension, including large and small artery remodeling and functional changes. Here, we review the recent literature on the alterations in small and large arteries in hypertension. We discuss the possible mechanisms underlying these abnormalities and we explain how they accompany and often precede hypertension. Finally, we propose an integrated pathophysiological approach to better understand how the cross-talk between large and small artery changes interacts in pressure wave transmission, exaggerates cardiac, brain and kidney damage, and lead to cardiovascular and renal complications. We focus on patients with essential hypertension because this is the most prevalent form of hypertension, and describe other forms of hypertension only for contrasting their characteristics with those of uncomplicated essential hypertension.read more
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Journal Article
Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors
TL;DR: This study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.
Journal ArticleDOI
A Call to Action and a Lifecourse Strategy to Address the Global Burden of Raised Blood Pressure on Current and Future Generations: The Lancet Commission on Hypertension
Michael H. Olsen,Michael H. Olsen,Sonia Y. Angell,Samira Asma,Pierre Boutouyrie,Dylan Burger,Julio A. Chirinos,Albertino Damasceno,Christian Delles,Anne Paule Gimenez-Roqueplo,Anne Paule Gimenez-Roqueplo,Dagmara Hering,Patricio Lopez-Jaramillo,Fernando Martinez,Vlado Perkovic,Ernst Rietzschel,Giuseppe Schillaci,Aletta E. Schutte,Angelo Scuteri,James E. Sharman,Kristian Wachtell,Ji-Guang Wang +21 more
TL;DR: The Commission has identified ten essential and achievable goals and ten accompanying, mutually additive, and synergistic key actions that—if implemented effectively and broadly—will make substantial contributions to the management of blood pressure globally.
Journal ArticleDOI
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
TL;DR: Current concepts of central pressure and tensile pulsatile circumferential stress as key mechanical determinants of arterial wall remodeling, cell-ECM interactions depending mainly on the architecture of cytoskeletal proteins and focal adhesion, the large/small arteries cross-talk that gives rise to target organ damage, and inflammatory pathways leading to calcification or atherosclerosis are summarized.
Journal ArticleDOI
Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association
Costantino Iadecola,Kristine Yaffe,José Biller,Lisa C. Bratzke,Frank M. Faraci,Philip B. Gorelick,Martha Gulati,Hooman Kamel,David S. Knopman,Lenore J. Launer,Jane S. Saczynski,Sudha Seshadri,Adina Zeki Al Hazzouri +12 more
TL;DR: Judicious treatment of hypertension, taking into account goals of care and individual characteristics (eg, age and comorbidities), seems justified to safeguard vascular health and, as a consequence, brain health.
Journal ArticleDOI
Oxidative Stress, Inflammation, and Vascular Aging in Hypertension.
Tomasz J. Guzik,Rhian M. Touyz +1 more
TL;DR: Oxidative stress and inflammation, key mechanisms of endothelial dysfunction and arterial damage, link these risk factors to vascular disease, arterial stiffness, and aging.
References
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Journal ArticleDOI
2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Robert Fagard,Krzysztof Narkiewicz,Josep Redon,Alberto Zanchetti,Michael Böhm,Thierry Christiaens,Renata Cifkova,Guy De Backer,Anna F. Dominiczak,Maurizio Galderisi,Diederick E. Grobbee,Tiny Jaarsma,Paulus Kirchhof,Sverre E. Kjeldsen,Stéphane Laurent,Athanasios J. Manolis,Peter M. Nilsson,Luis M. Ruilope,Roland E. Schmieder,Per Anton Sirnes,Peter Sleight,Margus Viigimaa,Bernard Waeber,Faiez Zannad,Michel Burnier,Ettore Ambrosioni,Mark Caufield,Antonio Coca,Michael H. Olsen,Costas Tsioufis,Philippe van de Borne,José Luis Zamorano,Stephan Achenbach,Helmut Baumgartner,Jeroen J. Bax,Héctor Bueno,Veronica Dean,Christi Deaton,Çetin Erol,Roberto Ferrari,David Hasdai,Arno W. Hoes,Juhani Knuuti,Philippe Kolh,Patrizio Lancellotti,Aleš Linhart,Petros Nihoyannopoulos,Massimo F Piepoli,Piotr Ponikowski,Juan Tamargo,Michal Tendera,Adam Torbicki,William Wijns,Stephan Windecker,Denis Clement,Thierry C. Gillebert,Enrico Agabiti Rosei,Stefan D. Anker,Johann Bauersachs,Jana Brguljan Hitij,Mark J. Caulfield,Marc De Buyzere,Sabina De Geest,Geneviève Derumeaux,Serap Erdine,Csaba Farsang,Christian Funck-Brentano,Vjekoslav Gerc,Giuseppe Germanò,Stephan Gielen,Herman Haller,Jens Jordan,Thomas Kahan,Michel Komajda,Dragan Lovic,Heiko Mahrholdt,Jan Östergren,Gianfranco Parati,Joep Perk,Jorge Polónia,Bogdan A. Popescu,Zeljko Reiner,Lars Rydén,Yuriy Sirenko,Alice Stanton,Harry A.J. Struijker-Boudier,Charalambos Vlachopoulos,Massimo Volpe,David A. Wood +89 more
TL;DR: In this article, a randomized controlled trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly people was presented. But the authors did not discuss the effect of the combination therapy in patients living with systolic hypertension.
Journal ArticleDOI
2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Guy De Backer,Anna F. Dominiczak,Renata Cifkova,Robert Fagard,Giuseppe Germanò,Guido Grassi,Anthony M. Heagerty,Sverre E. Kjeldsen,Stéphane Laurent,Krzysztof Narkiewicz,Luis M. Ruilope,Andrzej Rynkiewicz,Roland E. Schmieder,Harry A.J. Struijker Boudier,Alberto Zanchetti +15 more
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Journal ArticleDOI
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Stéphane Laurent,John R. Cockcroft,Luc M. Van Bortel,Pierre Boutouyrie,Cristina Giannattasio,Daniel Hayoz,Bruno Pannier,Charalambos Vlachopoulos,Ian B. Wilkinson,Harry A.J. Struijker-Boudier +9 more
TL;DR: This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Journal Article
Expert consensus document on arterial stiffness : methodological issues and clinical applications. Commentary
Michael F. O'Rourke,Stanley S. Franklin,Stéphane Laurent,John R. Cockcroft,Luc M. Van Bortel,Pierre Boutouyrie,Cristina Giannattasio,Daniel Hayoz,Bruno Pannier,Charalambos Vlachopoulos,Ian B. Wilkinson,Harry A.J. Struijker-Boudier +11 more
TL;DR: In this paper, the authors summarized the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Journal ArticleDOI
Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.
Stéphane Laurent,Pierre Boutouyrie,Roland Asmar,Isabelle Gautier,Brigitte Laloux,Louis Guize,Pierre Ducimetière,Athanase Benetos +7 more
TL;DR: This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
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