Journal ArticleDOI
The structure and stereochemistry of neoandrographolide, a diterpene glucoside from Andrographis paniculata nees
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TLDR
Neoandrographolide (2) is shown to be the β-glucoside of ent -19-hydroxy-8(17), 13-labdadien-16,15-olide as mentioned in this paper.About:
This article is published in Tetrahedron.The article was published on 1971-01-01. It has received 44 citations till now. The article focuses on the topics: Andrographis paniculata & Andrographolide.read more
Citations
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Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.
Jonathan Chee Woei Lim,Tze Khee Chan,David S.W. Ng,Sreenivasa Rao Sagineedu,Johnson Stanslas,W.S. Fred Wong,W.S. Fred Wong +6 more
TL;DR: An attempt is made to evaluate the phytochemical properties of the fruit extract of Andrographis paniculata which has potential in finding its application in medicine and herbal formulations.
Journal ArticleDOI
Flavonoids and andrographolides from Andrographis paniculata
TL;DR: Two flavonoids, identified as 5,7,2',3'-tetramethoxyflavanone and 5-hydroxy-7,3'-trimethoxyFlavone, as well as several other flavonoid, andrographolide diterpenoids, and polyphenols, were obtained from the phytochemical investigation of the whole plant of Andrographis paniculata.
Journal ArticleDOI
Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology
Agbonlahor Okhuarobo,Joyce Ehizogie Falodun,Osayemwenre Erharuyi,Osayemwenre Erharuyi,Vincent Imieje,Abiodun Falodun,Abiodun Falodun,Abiodun Falodun,Peter Langer +8 more
TL;DR: The results of numerous toxicity evaluations of extracts and metabolites isolated from this plant did not show any significant acute toxicity in experimental animals, so detailed and more comprehensive toxicity profile on mammalian tissues and organs is needed in future studies.
Journal ArticleDOI
Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata.
Virendra K. Dua,V. P. Ojha,Raja Roy,B.C. Joshi,Neena Valecha,C. Usha Devi,M. C. Bhatnagar,Vinod Sharma,Sarala K. Subbarao +8 more
TL;DR: In vivo anti-malarial sensitivity test of this compound on Swiss Albino mice with Plasmodium berghei infection using Peters' 4-day test gave substantial reduction in parasitaemia after treating the mice with 30 mg kg(-1) dose.
Journal ArticleDOI
Nain-e Havandi Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran's pharmaceutical plants.
Alireza Valdiani,Mihdzar Abdul Kadir,Soon Guan Tan,Daryush Talei,Mohd Puad Abdullah,Sonia Nikzad +5 more
TL;DR: Evidence implies the familiarity of Iran’s folkloric medicine with this plant, but it has been disappeared from contemporary medicine for unknown reasons, and availability of different ecological zones in Iran complies with reestablishment of AP in tropical and temperate regions of the country.
References
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Notes - Osmium Tetroxide-Catalyzed Periodate Oxidation of Olefinic Bonds
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Periodate–permanganate oxidations: i. oxidation of olefins
R. U. Lemieux,E. Von Rudloff +1 more
TL;DR: In this paper, it was discovered that olefinic double bonds are readily oxidized in an aqueous solution of periodate which contains only catalytic amounts of permanganate.
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The reduction of tosylhydrazones and of acyl tosylhydrazides
TL;DR: In this paper, the reduction of acyl-tosylhydrazides with LAH provides a new method for reducing a carbonyl group to a methyl group, and the intermediate alkyl-to-sylhydrazide formed in this reaction have been isolated.
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Andrographolide: Further transformations and stereochemical evidence; the structure of isoandrographolide
TL;DR: In this paper, a number of new transformation products of andrographolide and of its acid transformation product, isoandrograpolide, have been prepared; the structure of the iso-andrographylide has been elucidated; and the chemical results described afford proof of the stereochemistry at C-3 and C-9 of the bicyclic nucleus of androgramolide; the assigned configuration of the substituents at C -4 is supported by NMR study.
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Mass spectrometry as an aid for determining structures of natural glucosides
TL;DR: In this paper, mass spectral fragmentation patterns were determined for acetates of a number of glucosides of unequivocally known structure which have been isolated from the barks and leaves of trees of the family Salicaceae.