Journal ArticleDOI
The usefulness of C-reactive protein for the prediction of post-infarct left ventricular systolic dysfunction and heart failure
Iwona Swiatkiewicz,Pam R. Taub +1 more
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TLDR
Measurement of C-reactive protein (CRP) concentration reflecting an involvement of inflammatory pathways in post-infarct myocardial damage offers an attractive strategy to improve risk stratification and clinical decision-making for early management of high-risk patients.Abstract:
Acute myocardial infarction (MI) provokes a systemic inflammatory response that may contribute to the development of left ventricular systolic dysfunction (LVSD) and heart failure (HF). Patients with post-infarct HF with concomitant LVSD have the most unfavourable long-term prognosis. Measurement of C-reactive protein (CRP) concentration reflecting an involvement of inflammatory pathways in post-infarct myocardial damage offers an attractive strategy to improve risk stratification and clinical decision-making for early management of high-risk patients. Despite growing evidence for the prognostic value of CRP both as a single factor and as a component of multi-marker approach in MI, CRP measurement is not yet incorporated into current guidelines. This may be due to conflicting results reported in existing studies related to various limitations in study designs, such as retrospective case control design, prior myocardial damage, CRP measurement with low-sensitivity assays, non-homogenous populations with acute coronary syndromes, different treatment strategies, small sample sizes, and the lack of left ventricular ejection fraction assessment and long-term clinical and echocardiographic monitoring. As a result, previous studies have not provided conclusive evidence of the prognostic value of CRP for post-infarct LVSD or HF. Future studies with an adequate design including upstream mediators of inflammation as inflammatory markers are needed to identify the best biomarker-based strategies for identifying high-risk patients. Further clinical trials involving anti-inflammatory therapies target-ing different pathways of inflammatory activation in MI should test the inflammatory hypothesis of post-infarct LVSD and HF. Identifying high-risk patients with persistent post-infarct inflammatory response may allow incorporation of pathophysiological guidance for implementation of personalised treatment approaches.read more
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Journal ArticleDOI
Time-Restricted Eating and Metabolic Syndrome: Current Status and Future Perspectives.
TL;DR: Time-restricted eating (TRE) as discussed by the authors is a promising strategy for patients with metabolic syndrome (MetS) which aims at restoring robust circadian rhythms through modification of timing and duration of daily eating.
Journal ArticleDOI
Enhanced Inflammation is a Marker for Risk of Post-Infarct Ventricular Dysfunction and Heart Failure.
Iwona Świątkiewicz,Przemysław Magielski,Jacek Kubica,Adena Zadourian,Anthony N. DeMaria,Pam R. Taub +5 more
TL;DR: Elevated CRP concentration during STEMI can serve as a synergistic marker for risk of long-term LVSD and HF and patients with LVSD6M who developed HF had the highest CRP during index STEMI.
Journal ArticleDOI
Irreversible oxidative post-translational modifications in heart disease.
Tamara Tomin,Tamara Tomin,Matthias Schittmayer,Matthias Schittmayer,Sophie Honeder,Christoph Heininger,Ruth Birner-Gruenberger,Ruth Birner-Gruenberger +7 more
TL;DR: A chapter is dedicated to irreversible oxidative modifications, which trigger protein degradation pathways or cause protein aggregation, both influencing biomarker abundance, and their regulation in the heart.
Journal ArticleDOI
Effectiveness of Intensive Cardiac Rehabilitation in High-Risk Patients with Cardiovascular Disease in Real-World Practice.
Iwona Świątkiewicz,Iwona Świątkiewicz,Salvatore Di Somma,Ludovica De Fazio,Valerio Mazzilli,Pam R. Taub +5 more
TL;DR: In this paper, the authors evaluated intensive CR and standard CR programs for improving cardiometabolic, psychosocial, and clinical outcomes in high-risk CVD patients undergoing guideline-based therapies.
Journal ArticleDOI
C-Reactive Protein as a Risk Marker for Post-Infarct Heart Failure over a Multi-Year Period
TL;DR: In this article, the prognostic value of high-sensitivity C-reactive protein concentration (CRP) for post-infarct heart failure over a long-term follow-up in 204 patients with a first STEMI undergoing guideline-based therapies including percutaneous coronary intervention was determined.
References
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