Journal ArticleDOI
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors.
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Treatment of rats with ketanserin (3 mg/kg) completely prevented the hyperthermic effects of 5-MeODMT, and, in fact, converted ahyperthermic response to 5- MeODMT into a marked hypothermic response.About:
This article is published in Neuropharmacology.The article was published on 1986-12-01. It has received 286 citations till now. The article focuses on the topics: Xylamidine & Ketanserin.read more
Citations
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A review of central 5-HT receptors and their function
Nicholas M. Barnes,Trevor Sharp +1 more
TL;DR: A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.
Journal ArticleDOI
Paroxetine controlled release in the treatment of menopausal hot flashes: a randomized controlled trial.
TL;DR: Paroxetine CR may be an effective and acceptable alternative to hormone replacement and other therapies in treating menopausal hot flash symptoms and mean reductions in the hot flash frequency composite score from baseline to week 6 were statistically significantly greater for those receiving paroxETine CR than for those received placebo.
Journal ArticleDOI
Central serotonin and impulsive aggression.
TL;DR: Preliminary data with the 5- HT receptor agonist m-chlorophenylpiperazine suggest that reduced activity of post-synaptic 5-HT receptors may be an important correlate of impulsive aggressive behaviour in psychiatric patients.
Journal ArticleDOI
The Flinders sensitive line rats: a genetic animal model of depression.
TL;DR: The evidence in the present review indicates that the FSL rat model of depression fulfills the criteria of face, construct, and predictive validities.
Journal ArticleDOI
Toward a unified theory of serotonin dysregulation in eating and related disorders
TL;DR: Results from controlled studies in humans support the concept of altered post-synaptic, hypothalamic 5-HT receptor sensitivity in bulimia nervosa (BN), regardless of the presence of anorexia nervosa(AN) or major depression (MD), although these conditions may be associated with other disturbances in 5- HT function.
References
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Journal ArticleDOI
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
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The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.
TL;DR: The residual behavioural effects of 8-OH-DPAT in reserpinised rats may, therefore, reflect the consequences of stimulation of the putative 5-HT1A receptor.
Journal ArticleDOI
Discrimination of Multiple [3H]5-Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain
TL;DR: Saturation studies of [3H]5‐HT binding assayed in the absence or presence of 1 μM‐spiperone reveal a parallel shift in the Scatchard plot with no change in the dissociation constant of [2‐12 nM], but a significant decrease in the number of specific binding sites.
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An animal behavior model for studying central serotonergic synapses
Journal ArticleDOI
8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity
Stephan Hjorth,Arvid Carlsson,Per Lennart Lindberg,Domingo Sanchez,Håkan Wikström,L.-E. Arvidsson,Uli Hacksell,J. L. G. Nilsson +7 more
TL;DR: It was demonstrated that the simplified ergot congener 8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, is able to elicit pronounced biochemical and behavioural alterations indicative of central serotoninomimetic activity, and may be regarded the most potent, selective centrally acting 5-HT agonist described to date.
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A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors.
Guy M. Goodwin,A.R. Green +1 more