Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.
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TLDR
The depth of invasion was studied using the criteria for staging of Clark et al.2 to see if maximal cross-sectional area, thickness, stage of invasion, or a combination of these can be of value in assessing the prognosis of cutaneous melanoma.Abstract:
CuTANEous melanoma is a most unpredictable lesion. The marked variation in prognosis is probably a function of many variables, one of which is the size of the tumor. Though there is a roughly inverse relationship between the diameter of the lesion and survival,5 very small lesions have recurred or metastasized. One possible reason for the lack of reliability of tumor size in estimating prognosis may be that studies to date have considered size in only two diamensions and have neglected tumor volume. Two melanomas can have the same diameter but differ greatly in thickness because of variation in either depth of invasion or degree of protrusion from the surface of the skin or both. A recent study 2 has shown that prognosis correlates well with staging of the depth of invasion, but there have been no studies relating survival to tumor volume. To measure tumor volume it is necessary to know the surface area of the tumor, but in this retrospective study we only know the maximal diameters of the lesions. By measuring the maximal thickness of the lesions we can calculate the maximal crosssectional area, which should be roughly proportional to the volume of the tumor. The depth of invasion was also studied using the criteria for staging of Clark et al.2 to see if maximal cross-sectional area, thickness, stage of invasion, or a combination of these can be of value in assessing the prognosis of cutaneous melanoma. A total of 98 lesions were so studied.read more
Citations
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Epidemiology, staging (new system), and prognosis of cutaneous melanoma.
TL;DR: The 2002 American Joint Committee on Cancer tumor-nodes-metastasis staging classification incorporates Breslow depth, Clark's level, ulceration, pathologic microstaging attributes, and nodal and distant metastases.
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Identification of higher risk thin melanomas should be based on Breslow depth not Clark level IV
Sylvia A. Owen,Linda L. Sanders,Lloyd J. Edwards,Hilliard F. Seigler,Douglas S. Tyler,James M. Grichnik +5 more
TL;DR: There is good prognostic correlation for the two microstaging systems, Breslow depth and Clark level, commonly used to stage melanomas, and the authors sought to determine whether this is appropriate, based on melanoma patient data in the Duke Comprehensive Cancer Center database.
Journal ArticleDOI
Melanoma of the external ear.
David J. Cole,Gregory J. Mackay,Bruce F. Walker,William A. Wooden,Douglas R. Murray,John J. Coleman,John J. Coleman +6 more
TL;DR: There is no evidence that melanoma of the ear has a poorer prognosis or different prognostic factors than melanoma at other cutaneous sites, and in selected cases, local disease can be controlled by excision and skin graft rather than the more aggressive current procedures.
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Malignant melanoma of the ear.
TL;DR: The thickness of the tumour is of greater prognostic value than the estimation of proliferation by PCNA and vascularization by CD31, and the value ofPCNA and CD31 as possible prognostic parameters needs to be evaluated in a larger series.
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Malignant melanoma of the vulva: A clinicopathologic study of 18 cases
TL;DR: Since the data with respect to microstaging of vulvar malignant melanoma is, as yet, still limited, great caution should be used in electing less aggressive surgery than radical vulvectomy and bilateral groin lymphadenectomy for patients with early‐microstage localized disease.
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