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Open AccessJournal ArticleDOI

Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.

Alexander Breslow
- 01 Nov 1970 - 
- Vol. 172, Iss: 5, pp 902-908
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TLDR
The depth of invasion was studied using the criteria for staging of Clark et al.2 to see if maximal cross-sectional area, thickness, stage of invasion, or a combination of these can be of value in assessing the prognosis of cutaneous melanoma.
Abstract
CuTANEous melanoma is a most unpredictable lesion. The marked variation in prognosis is probably a function of many variables, one of which is the size of the tumor. Though there is a roughly inverse relationship between the diameter of the lesion and survival,5 very small lesions have recurred or metastasized. One possible reason for the lack of reliability of tumor size in estimating prognosis may be that studies to date have considered size in only two diamensions and have neglected tumor volume. Two melanomas can have the same diameter but differ greatly in thickness because of variation in either depth of invasion or degree of protrusion from the surface of the skin or both. A recent study 2 has shown that prognosis correlates well with staging of the depth of invasion, but there have been no studies relating survival to tumor volume. To measure tumor volume it is necessary to know the surface area of the tumor, but in this retrospective study we only know the maximal diameters of the lesions. By measuring the maximal thickness of the lesions we can calculate the maximal crosssectional area, which should be roughly proportional to the volume of the tumor. The depth of invasion was also studied using the criteria for staging of Clark et al.2 to see if maximal cross-sectional area, thickness, stage of invasion, or a combination of these can be of value in assessing the prognosis of cutaneous melanoma. A total of 98 lesions were so studied.

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Citations
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Histopathologic classification and prognostic factors of melanoma: a 2021 update.

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Delay in cutaneous melanoma diagnosis: Sequence analyses from suspicion to diagnosis in 211 patients.

TL;DR: A deficient knowledge in the population regarding melanoma and physicians’ misdiagnoses regarding suspicious lesions contributed to delays in diagnosis.
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An Accelerated System for Melanoma Diagnosis Based on Subset Feature Selection

TL;DR: An optimised system for diagnosing skin lesions based on digitized dermatoscopic color images and focuses particularly on the critical step of the features selection allowing to select a reasonable reduced number of useful features while removing redundant information and approximating the properties of melanoma recognition.
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Acral melanoma. A clinicopathologic study of 28 patients.

TL;DR: Of the 81 patients with cutaneous malignant melanoma, 28 (35%) had acral melanoma and the preferential sites for metastasis were the lymph nodes, followed by the lungs, bone, and liver in descending order.
References
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Journal ArticleDOI

Some Methods for Strengthening the Common χ 2 Tests

TL;DR: In this article, the authors discuss two kinds of failure to make the best use of x2 tests which I have observed from time to time in reading reports of biological research, and propose a number of methods for strengthening or supplementing the most common uses of the ordinary x2 test.
Journal Article

The Histogenesis and Biologic Behavior of Primary Human Malignant Melanomas of the Skin

TL;DR: Evidence is presented suggesting that superficial spreading melanoma and lentigo maligna melanoma (Hutchinson9s melanotic freckle) show a long period of superficial growth, followed by the relatively rapid appearance of nodules or deeper invasion within the primary lesion.
Journal ArticleDOI

The Detection of Partial Association, I: The 2 × 2 Case

TL;DR: In this article, a criterion for testing null hypotheses of conditional independence of two dichotomous random variables is derived for testing whether the association of the two random variables in the conditional distribution is, in a certain sense, constant.
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