Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.
Reads0
Chats0
TLDR
The depth of invasion was studied using the criteria for staging of Clark et al.2 to see if maximal cross-sectional area, thickness, stage of invasion, or a combination of these can be of value in assessing the prognosis of cutaneous melanoma.Abstract:
CuTANEous melanoma is a most unpredictable lesion. The marked variation in prognosis is probably a function of many variables, one of which is the size of the tumor. Though there is a roughly inverse relationship between the diameter of the lesion and survival,5 very small lesions have recurred or metastasized. One possible reason for the lack of reliability of tumor size in estimating prognosis may be that studies to date have considered size in only two diamensions and have neglected tumor volume. Two melanomas can have the same diameter but differ greatly in thickness because of variation in either depth of invasion or degree of protrusion from the surface of the skin or both. A recent study 2 has shown that prognosis correlates well with staging of the depth of invasion, but there have been no studies relating survival to tumor volume. To measure tumor volume it is necessary to know the surface area of the tumor, but in this retrospective study we only know the maximal diameters of the lesions. By measuring the maximal thickness of the lesions we can calculate the maximal crosssectional area, which should be roughly proportional to the volume of the tumor. The depth of invasion was also studied using the criteria for staging of Clark et al.2 to see if maximal cross-sectional area, thickness, stage of invasion, or a combination of these can be of value in assessing the prognosis of cutaneous melanoma. A total of 98 lesions were so studied.read more
Citations
More filters
Journal ArticleDOI
Lentigo maligna and lentigo maligna melanoma
TL;DR: The clinical, histopathologic, and epidemiologic features of LM, a pigmented lesion that occurs on the sun-exposed skin, particularly the head and neck areas, of an older patient, are discussed.
Journal ArticleDOI
Gene Expression Signatures for Tumor Progression, Tumor Subtype, and Tumor Thickness in Laser-Microdissected Melanoma Tissues
Jochen Jaeger,Dirk Koczan,H.-J. Thiesen,Saleh M. Ibrahim,Gerd Gross,Rainer Spang,Manfred Kunz +6 more
TL;DR: This large-scale gene expression study of malignant melanoma identified molecular signatures related to metastasis, melanoma subtypes, and tumor thickness that may help guide future research on innovative treatments.
Journal ArticleDOI
Randomized, surgical adjuvant clinical trial of recombinant interferon alfa-2a in selected patients with malignant melanoma.
Edward T. Creagan,Robert J. Dalton,D. L. Ahmann,Sin-Ho Jung,Roscoe F. Morton,R. M. Langdon,John W. Kugler,L. J. Rodrigue +7 more
TL;DR: Findings indicate trends that suggest a possible benefit for selected patients with high-risk malignant melanoma, which will require further study in a larger patient population for confirmation.
Journal ArticleDOI
Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study.
Soledad Alonso,Pablo Ortiz,Marina Pollán,Beatriz Pérez-Gómez,Lydia Sánchez,Ma Jesús Acuña,Raquel Pajares,Francisco J. Martinez-Tello,Carlos M. Hortelano,Miguel A. Piris,José Luis Rodríguez-Peralto +10 more
TL;DR: In this paper, a panel of 39 different antibodies for cell cycle, apoptosis, melanoma antigens, transcription factors, DNA mismatch repair, and other proteins was used to identify expression profiles distinguishing specific melanoma progression stages.
Journal ArticleDOI
Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases.
TL;DR: The impact of nodal tumor burden on patterns of relapse and survival was retrospectively analyzed in 1001 patients with stage III melanoma, finding that patients with 1 "positive" node had a 45% 5-year and 39% 10-year survival rate.
References
More filters
Journal ArticleDOI
Some Methods for Strengthening the Common χ 2 Tests
TL;DR: In this article, the authors discuss two kinds of failure to make the best use of x2 tests which I have observed from time to time in reading reports of biological research, and propose a number of methods for strengthening or supplementing the most common uses of the ordinary x2 test.
Journal Article
The Histogenesis and Biologic Behavior of Primary Human Malignant Melanomas of the Skin
TL;DR: Evidence is presented suggesting that superficial spreading melanoma and lentigo maligna melanoma (Hutchinson9s melanotic freckle) show a long period of superficial growth, followed by the relatively rapid appearance of nodules or deeper invasion within the primary lesion.
Journal ArticleDOI
The Detection of Partial Association, I: The 2 × 2 Case
TL;DR: In this article, a criterion for testing null hypotheses of conditional independence of two dichotomous random variables is derived for testing whether the association of the two random variables in the conditional distribution is, in a certain sense, constant.
Journal ArticleDOI
Clinicopathological correlations in a series of 117 malignant melanomas of the skin of adults.
Related Papers (5)
The Histogenesis and Biologic Behavior of Primary Human Malignant Melanomas of the Skin
Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma
Charles M. Balch,Antonio C. Buzaid,Seng Jaw Soong,Michael B. Atkins,Natale Cascinelli,Daniel G. Coit,Irvin D. Fleming,Jeffrey E. Gershenwald,Alan Houghton,John M. Kirkwood,Kelly M. McMasters,Martin F. Mihm,Donald L. Morton,Douglas S. Reintgen,M. I. Ross,Arthur J. Sober,John A. Thompson,John F. Thompson +17 more
Final Version of 2009 AJCC Melanoma Staging and Classification
Charles M. Balch,Jeffrey E. Gershenwald,Seng-Jaw Soong,John F. Thompson,Michael B. Atkins,David R. Byrd,Antonio C. Buzaid,Alistair J. Cochran,Daniel G. Coit,Shouluan Ding,Alexander M.M. Eggermont,Keith T. Flaherty,Phyllis A. Gimotty,John M. Kirkwood,Kelly M. McMasters,Martin C. Mihm,Donald L. Morton,Merrick I. Ross,Arthur J. Sober,Vernon K. Sondak +19 more
Prognostic Factors Analysis of 17,600 Melanoma Patients: Validation of the American Joint Committee on Cancer Melanoma Staging System
Charles M. Balch,Seng Jaw Soong,Jeffrey E. Gershenwald,John F. Thompson,Douglas S. Reintgen,Natale Cascinelli,Marshall M. Urist,Kelly M. McMasters,M. I. Ross,John M. Kirkwood,Michael B. Atkins,John A. Thompson,Daniel G. Coit,David R. Byrd,Renee A. Desmond,Yuting Zhang,Ping-Yu Liu,Gary H. Lyman,Aberto Morabito +18 more