Journal ArticleDOI
Thiolated polymers — thiomers: development and in vitro evaluation of chitosan–thioglycolic acid conjugates
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TLDR
It could be shown that chitosan-TGA conjugates are still biodegradable by the glycosidase lysozyme and represent a promising tool for the development of mucoadhesive drug delivery systems.About:
This article is published in Biomaterials.The article was published on 2001-09-01. It has received 451 citations till now. The article focuses on the topics: Thiomer & Thioglycolic acid.read more
Citations
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Chitosan chemistry and pharmaceutical perspectives.
TL;DR: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. S. Nagar, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of medicine, Jerusalem 91120, Israel.
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Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
Meera George,T. Emilia Abraham +1 more
TL;DR: Alginate, being an anionic polymer with carboxyl end groups, is a good mucoadhesive agent and cross-linked alginate has more capacity to retain the entrapped drugs and mixing of alginates with other polymers such as neutral gums, chitosan, and eudragit have been found to solve the problem of drug leaching.
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The basics and underlying mechanisms of mucoadhesion.
TL;DR: New mucoadhesive materials with optimal adhesive properties are now being developed, and these should enhance the potential applications of this technology.
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Chitosan-modifications and applications: Opportunities galore
V.K. Mourya,Nazma N. Inamdar +1 more
TL;DR: The chemical modification affords a wide range of derivatives with modified properties for specific end use applications in diversified areas mainly of pharmaceutical, biomedical and biotechnological fields.
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The use of mucoadhesive polymers in ocular drug delivery.
TL;DR: In the present update on mucoadhesive ocular dosage forms, the tremendous advances in the biochemistry of mucins, the development of new polymers, the use of drug complexes and other technological advances are discussed.
References
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Chitosan and Its Use as a Pharmaceutical Excipient
TL;DR: The transmucosal absorption promoting characteristics of chitosan has been exploited especially for nasal and oral delivery of polar drugs to include peptides and proteins and for vaccine delivery.
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In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
TL;DR: A number of natural or partially modified polymers were screened for muco-adhesive properties by routinely measuring the force of detachment for swollen polymer films from pig intestinal mucosa in a saline medium.
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Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement
Nicolaas G. M. Schipper,Susanne Olsson,Janet Hoogstraate,Albertus G. deBoer,Kjell M. Vårum,Per Artursson +5 more
TL;DR: The binding and absorption enhancing effects of chitosans on epithelial cells are mediated through their positive charges, which results in a structural reorganisation of tight junction-associated proteins which is followed by enhanced transport through the paracellular pathway.
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Pharmaceutical applications of chitosan
TL;DR: The authors outline the major new approaches to the pharmaceutical applications of chitosan and discuss its mechanisms of action in various in vitro and in vivo models.
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Effect of chitosan on epithelial permeability and structure.
TL;DR: The data suggest that chitosan increases cell permeability by affecting paracellular and intracellular pathways of epithelial cells, in a reversible manner.