Three-component carboacylation of alkenes via cooperative nickelaphotoredox catalysis
Dingyi Wang,Lutz Ackermann +1 more
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In this paper , various commercially available acyl chlorides, aldehydes, and alkanes were exploited for versatile three-component 1,2-carboacylations of alkenes to forge two vicinal C-C bonds through the cooperative action of nickel and sodium decatungstate catalysis.Abstract:
Various commercially available acyl chlorides, aldehydes, and alkanes were exploited for versatile three-component 1,2-carboacylations of alkenes to forge two vicinal C–C bonds through the cooperative action of nickel and sodium decatungstate catalysis. A wealth of ketones with high levels of structural complexity was rapidly obtained via direct functionalization of C(sp2)/C(sp3)–H bonds in a modular manner. Furthermore, a regioselective late-stage modification of natural products showcased the practical utility of the strategy, generally featuring high resource economy and ample substrate scope.read more
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Dual NHC/photoredox catalytic synthesis of 1,4-diketones using an MR-TADF photocatalyst (DiKTa).
TL;DR: In this paper , the use of the recently reported organic multi-resonant thermally activated delayed fluorescence (MR-TADF) photocatalyst DiKTa allows for the modular synthesis of 1,4-diketones under mild and metal-free conditions.
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General Method for Selective Three-Component Carboacylation of Alkenes via Visible-Light Dual Photoredox/Nickel Catalysis.
TL;DR: A photoredox/nickel dual catalytic protocol for the regioselective three-component carboacylation of alkenes with tertiary and secondary alkyltrifluoroborates as well as acyl chlorides is described in this article .
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Recent Advances in Nonprecious Metal Catalysis
TL;DR: In this article , the authors highlight selected articles published from March to June 2022 which are intended to highlight examples of NPMC that they feel may be especially relevant to pharmaceutical development.
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Ruthenium-Catalyzed Remote-Difunctionalization of Nonactivated Alkenes for Double meta-C(sp2)-H/C-6(sp3)-H Functionalization.
TL;DR: In this paper , a ruthenium-catalyzed remote 1,n-difunctionalization of nonactivated alkenes with fluoroalkyl halides and heteroarenes was reported.
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Radical Acylation: Concepts, Synthetic Applications and Directions
TL;DR: Ketones could serve as prevalent structural cores in natural products, pharmaceuticals, and materials sciences as mentioned in this paper , and synthesizing of ketones is one of the most addressed problems in organic chemistry.
References
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Dual Catalysis Strategies in Photochemical Synthesis
TL;DR: This Review summarizes dual-catalyst strategies that have been applied to synthetic photochemistry, and focuses upon the cooperative interactions of photocatalysts with redox mediators, Lewis and Brønsted acids, organocatalyst, enzymes, and transition metal complexes.
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The merger of transition metal and photocatalysis
TL;DR: The combination of Photoredox catalysis and transition metal catalysis is reviewed to show how this provides access to highly reactive oxidation states of transition metals and distinct activation modes that further enable the synthetic chemist.
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Addition of CF3 across unsaturated moieties: a powerful functionalization tool
Estíbaliz Merino,Cristina Nevado +1 more
TL;DR: This review summarizes recent methodologies for the simultaneous formation of C–CF3 and C–C or C–heteroatom bonds by formal addition reactions to alkenes.
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Radicals: Reactive Intermediates with Translational Potential
TL;DR: This Perspective illustrates the defining characteristics of free radical chemistry, beginning with its rich and storied history, and studies from the laboratory are discussed along with recent developments emanating from others in this burgeoning area.
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Transition Metal Catalyzed Alkene and Alkyne Hydroacylation
TL;DR: Intermolecular Alkene Hydroacylation 3.2.1.