Journal ArticleDOI
Three-dimensional acousto-optic imaging in biological tissues with parallel signal processing.
TLDR
This work describes an original acousto-optic method that allows one to reveal optical contrasts through biological tissues that are several centimeters thick with a millimeter-sized resolution and improves the observed degree of modulation by 2 orders of magnitude.Abstract:
An original acousto-optic method is described that allows one to reveal optical contrasts through biological tissues that are several centimeters thick with a millimeter-sized resolution. This technique is based on the interaction of scattered laser light with a focused ultrasonic field. The modulation depth of the optical speckle is related to local optical properties of the sample. Our parallel-processing approach to the demodulation of the speckle improves the observed degree of modulation by 2 orders of magnitude and quickly yields a good statistical value. Optically absorbing objects were imaged inside 35-mm-thick biological tissues.read more
Citations
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Journal ArticleDOI
Shot-noise detection of ultrasound-tagged photons in ultrasound-modulated optical imaging
TL;DR: A new detection method for ultrasound-modulated optical tomography that allows to perform parallel speckle detection with optimum shot-noise sensitivity, using a CCD camera, is proposed and it is shown that making use of a spatial filter system allows to fully filter out Speckle decorrelation noise.
Journal ArticleDOI
Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles
Jun Li,Geng Ku,Lihong V. Wang +2 more
TL;DR: Ultrasound-modulated optical tomography based on the measurement of laser-speckle contrast was investigated and the contrast of the speckle pattern formed by the transmitted light was found to depend on the ultrasonic modulation and could be used for imaging.
Journal ArticleDOI
State-of-the art of acousto-optic sensing and imaging of turbid media
TL;DR: Different schemes will be discussed to detect the modulated photons based on speckle detection, heterodyne detection, photorefractive crystal (PRC) assisted detection, and spectral hole burning as well as Fabry-Perot interferometers.
Journal ArticleDOI
Methods for parallel-detection-based ultrasound-modulated optical tomography.
Jun Li,Lihong V. Wang +1 more
TL;DR: The research reported here focuses on ultrasound-modulated optical tomography based on parallel speckle detection, which has advantages in reducing acquisition time and improving the signal-to-noise ratio.
Journal ArticleDOI
Towards non-contact photoacoustic imaging [review].
TL;DR: This paper presents a brief overview of current non-contact photoacoustic detection techniques with an emphasis on all-optical detection methods and their associated physical mechanisms.
References
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Wolfgang Drexler,Uwe Morgner,Franz X. Kärtner,Costas Pitris,Stephen A. Boppart,Xingde Li,Erich P. Ippen,James G. Fujimoto +7 more
TL;DR: To overcome depth-of-field limitations the authors perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth, which is to their knowledge the highest longitudinal resolution demonstrated to date for in vivo OCT imaging.
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Three-dimensional photoacoustic imaging of blood vessels in tissue
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Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design.
Andrew M. Rollins,Rujchai Ung-arunyawee,Amitabh Chak,Richard C.K. Wong,Kenji Kobayashi,Michael V. Sivak,Joseph A. Izatt +6 more
TL;DR: In initial clinical studies using the EOCT system, the esophagus, stomach, duodenum, ileum, colon, and rectum of patients with normal endoscopic findings were examined; microscopic structures such as glands, blood vessels, pits, villi, and crypts were also observed.
Journal ArticleDOI
Continuous-wave ultrasonic modulation of scattered laser light to image objects in turbid media.
TL;DR: Continuous-wave ultrasonic modulation of scattered laser light has been used to image objects in tissue-simulating turbid media for what is to the authors' knowledge the first time and has the potential to provide a noninvasive, nonionizing, inexpensive diagnostic tool for diseases such as breast cancer.
Journal ArticleDOI
Ultrasonic modulation of multiply scattered light
TL;DR: In this article, the first observation of ultrasonic modulation of multiple light scattering speckles was reported, where the modulation at 2 MHz of the temporal field autocorrelation function of the light scattered from concentrated aqueous suspensions of polystytrene beads was measured.