Journal ArticleDOI
Thymidine Kinase as a Proliferative Marker: Clinical Relevance in 1,692 Primary Breast Cancer Patients
Philippe Broët,Romain S,A Daver,G Ricolleau,V Quillien,A. Rallet,Bernard Asselain,P M Martin,Frédérique Spyratos +8 more
TLDR
High TK values are an important risk factor in node-negative patients and seem to be associated with a beneficial effect of adjuvant FAC or FEC in patients who received adjUvant chemotherapy.Abstract:
PURPOSE: To assess the prognostic value of thymidine kinase (TK), an enzyme involved in the DNA synthesis salvage pathway, relative to other prognostic factors in primary breast cancer. PATIENTS AND METHODS: This retrospective study involved 1,692 patients with operable breast cancer treated in six institutions (median follow-up, 82 months). Among the 857 node-negative patients, 135 received adjuvant chemotherapy (fluorouracil, doxorubicin, cyclophosphamide [FAC] or fluorouracil, etoposide, and cisplatin [FEC]). TK was assayed in cytosol with a quantitative radioenzymatic technique. Disease-specific survival (DSS), local recurrence-free interval (LRI), and distant-relapse-free interval (DRI) were investigated. RESULTS: High TK levels were associated with large tumor size, high histologic grade, and steroid hormone receptor negativity. Univariate analysis of the entire data set showed that high TK levels were related to shorter DSS (P < 10-5), LRI (P < 10-3), and DRI (P < 10-5). In time-dependent Cox model...read more
Citations
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Journal ArticleDOI
5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future
Sona Vodenkova,Tomas Buchler,Klara Cervena,Veronika Veskrnova,Pavel Vodicka,Veronika Vymetalkova,Veronika Vymetalkova,Veronika Vymetalkova +7 more
TL;DR: A comprehensive review summarizing options of CRC treatment and the mechanisms of 5-FU action at the molecular level, including both anabolic and catabolic ways is presented.
Journal ArticleDOI
Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?
Maria Antonetta Colozza,Evandro de Azambuja,Fatima Cardoso,Christos Sotiriou,Denis Larsimont,Martine Piccart +5 more
TL;DR: The present paper critically reviews the current knowledge about the following markers: thymidine labeling index, S phase fraction/flow cytometry, Ki 67, Thymidine kinase (TK), cyclins E, cyclin D, the cyclin inhibitors p27 and p21, and topoisomerase IIalpha.
Journal ArticleDOI
A multicolor nanoprobe for detection and imaging of tumor-related mRNAs in living cells.
TL;DR: A multicolor fluorescence nanoprobe based on nanoflares, which simultaneously detects three intracellular tumor-related mRNAs and brings new opportunities for improving the accuracy of early cancer detection over the single-marker assay.
Journal ArticleDOI
FRET Nanoflares for Intracellular mRNA Detection: Avoiding False Positive Signals and Minimizing Effects of System Fluctuations
TL;DR: The upgraded FRET nanoflares can avoid false positive signals by chemical interferences (such as nuclease and GSH) and thermodynamic fluctuations and can be easily made with ratiometric measurement, minimizing the effect of system fluctuations.
Journal ArticleDOI
Correlation between MIB-1 and other proliferation markers: clinical implications of the MIB-1 cutoff value.
Frédérique Spyratos,Magali Ferrero-Poüs,Martine Trassard,Kamel Hacène,Edelmira Phillips,Michèle Tubiana-Hulin,Viviane Le Doussal +6 more
TL;DR: The objectives of this study were to compare MIB‐1 evaluation to other methods of measuring cell proliferation, with a view to refining the cutoff used to classify tumors with low and high proliferation rates in therapeutic trials.
References
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Asymptotically Efficient Rank Invariant Test Procedures
Richard Peto,Julian Peto +1 more
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Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.
H. J. G. Bloom,W. W. Richardson +1 more
TL;DR: This is a selection of photographs from around the world taken in the period of May 21 to 29, 1997, which were taken at the request of the then-president of the United States, George W. Bush.