Journal ArticleDOI
Tolerance to lipopolysaccharide in human blood monocytes.
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TLDR
The data add to the notion that p50 binding to the cognate -kB DNA motif in the TNF promoter may be responsible for the unresponsiveness in LPS tolerance, by showing that similar mechanisms apply to primary blood monocytes.About:
This article is published in Immunobiology.The article was published on 1995-07-01. It has received 56 citations till now. The article focuses on the topics: CD14 & Tumor necrosis factor alpha.read more
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Book ChapterDOI
Neutrophil-Derived Proteins: Selling Cytokines by the Pound
TL;DR: This chapter discusses the ability of neutrophils to synthesize and release various cytokines and suggests that under some circumstances, the contribution of PMN-derived cytokines can be of foremost importance to the evolution of certain pathologies.
Journal ArticleDOI
The impact of systemic infection on the progression of neurodegenerative disease
TL;DR: There is emerging evidence to support the idea that nonspecific systemic infection or inflammation in people with existing inflammation in the brain contributes to the rate of disease progression through further activation of these already primed macrophages.
Journal ArticleDOI
Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88
TL;DR: The regulated expression and antagonistic activity of MyD88(S), which encodes for a protein lacking the ID, suggest an important role for alternative splicing of Myd88 in the regulation of the cellular response to IL-1 and LPS.
Journal ArticleDOI
Toll-like receptors.
Egil Lien,Robin R. Ingalls +1 more
TL;DR: Signals initiated by the interaction of TLRs with specific microbial patterns direct the subsequent inflammatory response, and TLR signaling represents a key component of the innate immune response to microbial infection.
Journal ArticleDOI
Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen.
TL;DR: It is established that cyclooxygenase-2-dependent arachidonic acid metabolites are essential in the development and maintenance of intestinal immune homeostasis.
References
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Journal ArticleDOI
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
Journal ArticleDOI
I kappa B: a specific inhibitor of the NF-kappa B transcription factor.
TL;DR: The data show the existence of a phorbol ester-responsive regulatory protein that acts by controlling the DNA binding activity and subcellular localization of a transcription factor in cells that do not express immunoglobulin kappa light chain genes.
Journal ArticleDOI
Bacterial endotoxin: molecular relationships of structure to activity and function.
E. T. Rietschel,Teruo Kirikae,F U Schade,Uwe Mamat,Schmidt G,Harald Loppnow,Artur J. Ulmer,Ulrich Zähringer,Ulrich Seydel,F Di Padova +9 more
TL;DR: The biological analysis of synthetic lipid A partial structures proved that the expression of endotoxic activity depends on a unique primary structure and a peculiar endotoxic conformation, and molecular and submolecular details of the specificity of the interaction of lipid A with responsive host cells are determined.
Journal ArticleDOI
Turning off the signal: desensitization of beta-adrenergic receptor function.
TL;DR: The molecular mechanisms underlying rapid βAR desensitization do not appear to require internalization of the receptors, but rather an alteration in the functioning of βAR themselves that uncouples the receptors from the stimulatory G protein Gs.
Journal ArticleDOI
The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.
M.L. Schmitz,Patrick A. Baeuerle +1 more
TL;DR: The study suggests that the p50 subunit in NF‐kappa B might only serve a helper function in DNA binding whereas the p65 subunit is responsible for initiating transcription.