Journal ArticleDOI
Total Synthesis of Natural tert-Alkylamino Hydroxy Carboxylic Acids
About:
This article is published in Chemical Reviews.The article was published on 2005-09-20. It has received 90 citations till now. The article focuses on the topics: Total synthesis.read more
Citations
More filters
Journal ArticleDOI
Catalytic asymmetric alkylations of ketoimines. Enantioselective synthesis of N-substituted quaternary carbon stereogenic centers by Zr-catalyzed additions of dialkylzinc reagents to aryl-, alkyl-, and trifluoroalkyl-substituted ketoimines.
TL;DR: The utility of the catalytic asymmetric protocols is illustrated through conversion of the enantiomerically enriched alkylation products to a range of cyclic and acyclic compounds bearing an N-substituted quaternary carbon stereogenic center.
Journal ArticleDOI
Total synthesis of a chlorosulpholipid cytotoxin associated with seafood poisoning
TL;DR: The synthesis of a chlorosulpholipid cytotoxin is reported, leading to confirmation of the proposed structure and the discovery of unanticipated reactivity of polychlorinated hydrocarbons.
Journal ArticleDOI
Synthetic approaches towards alkaloids bearing α-tertiary amines
TL;DR: Some approaches to asymmetrically access ATAs are reviewed and an overview of alkaloid total syntheses where those have been employed is provided and it is provided that fewer methods than previously described are commonly used in synthesis.
Journal ArticleDOI
Stereoselective syntheses of quaternary substituted α-amino acids using oxazol-5-(4H)-ones
TL;DR: The present mini-review gives an overview of stereoselective syntheses of quaternary α-amino acids produced from racemic oxazolones.
Journal ArticleDOI
Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry.
TL;DR: This review covers recent developments in medicinal chemistry of natural and synthetic proteasome inhibitors and new structures and new modes of action have been recently identified that open the door to new drug candidates for treating a range of diseases.
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines
Journal ArticleDOI
Catalytic Asymmetric Dihydroxylation
Book
Catalytic Asymmetric Synthesis
TL;DR: Asymmetric Hydrogenation (T. Ohkuma, et al. as discussed by the authors ), asymmetric carbon-Carbon Bond-Forming Reactions (K. Nozaki & I. Negishi). Asymmetric Addition and Insertion Reactions of Catalytically-Generated Metal Carbenes (M. O'Donnell), and asymptotic phase-transfer Reactions.
Book
Comprehensive asymmetric catalysis
TL;DR: Ohkuma et al. as mentioned in this paper proposed an asymmetric Dihydroxylation process for carbon-Carbon double bonds and showed that it can be used for allylation of C=O.
Related Papers (5)
Enantio‐ and Diastereoselective Construction of α,α‐Disubstituted α‐Amino Acids for the Synthesis of Biologically Active Compounds
Yasufumi Ohfune,Tetsuro Shinada +1 more
Recent approaches towards the asymmetric synthesis of α,α-disubstituted α-amino acids
Henning Vogt,Stefan Bräse +1 more