Journal ArticleDOI
Treatment Beyond Progression in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab in CheckMate 025.
Bernard Escudier,Robert J. Motzer,Padmanee Sharma,John Wagstaff,Elizabeth R. Plimack,Hans J. Hammers,Frede Donskov,Howard Gurney,Jeffrey A. Sosman,Pawel Zalewski,Ulrika Harmenberg,David F. McDermott,Toni K. Choueiri,Martin Eduardo Richardet,Yoshihiko Tomita,Alain Ravaud,Justin Doan,Huanyu Zhao,Helene Hardy,Saby George +19 more
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TLDR
A subset of patients with advanced renal cell carcinoma and disease progression may continue to benefit from nivolumab treatment beyond progression as evidenced by tumor reduction postprogression and an acceptable safety profile.About:
This article is published in European Urology.The article was published on 2017-09-01. It has received 187 citations till now. The article focuses on the topics: Nivolumab & Response Evaluation Criteria in Solid Tumors.read more
Citations
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Journal ArticleDOI
Real-World Metastatic Renal Cell Carcinoma Treatment Patterns and Clinical Outcomes in The Netherlands
Sylvia A van Laar,Kim B. Gombert-Handoko,Rolf H.H. Groenwold,T. van der Hulle,L. Visser,Danny Houtsma,H-J Guchelaar,Juliette Zwaveling +7 more
TL;DR: With most patients starting on pazopanib and sunitinib, these real-world treatment outcomes were most likely better than in pivotal trials, which may be due to extensive follow-up treatments.
Journal ArticleDOI
Interdisziplinäre Empfehlungen zur Behandlung des fortgeschrittenen Nierenzellkarzinoms
Kurt Miller,Lothar Bergmann,Christian Doehn,Viktor Grünwald,Jürgen E. Gschwend,Philipp Ivanyi,Ulrich Keilholz,Markus A. Kuczyk +7 more
TL;DR: Thema nach der optimalen Sequenztherapie muss aufgrund des Einzugs von CPI in die Erstlinie neu diskutiert werden, da die meisten Optionen nach Versagen einer VEGF-gerichteten TKI-Therapie gepruft wurden.
Journal ArticleDOI
Atypical Response Patterns in Renal Cell Carcinoma Treated with Immune Checkpoint Inhibitors—Navigating the Radiologic Potpourri
Alvin Wong,Balamurugan Vellayappan,Lenith Cheng,Joseph J. Zhao,Vaishnavi Muthu,Yugarajah Asokumaran,Jia-Li Low,Matilda Lee,Yiqing Huang,Nesaretnam Barr Kumarakulasinghe,Natalie Ngoi,Cheng-Nang Leong,Wynne Chua,Yee-Liang Thian +13 more
TL;DR: A detailed lesion-by-lesion analysis of the serial imaging of 46 renal cell carcinoma (RCC) patients treated with ICIs with the aim of capturing the full range of radiologic behaviour was performed in this paper.
Journal ArticleDOI
Atypical response patterns in metastatic melanoma and renal cell carcinoma patients treated with nivolumab: A single center experience:
TL;DR: This study aimed to assess the frequency of hyperprogression and pseudoprogression in metastatic RCC and melanoma patients treated in the authors' institution with the programmed cell death protein–1 inhibitor nivolumab.
Journal ArticleDOI
Combination therapy with nivolumab (anti-PD-1 monoclonal antibody): A new era in tumor immunotherapy.
B. Abedi Kiasari,Arash Abbasi,Nadia Ghasemi Darestani,Nasim Adabi,A. Moradian,Yalda Yazdani,Golsa Sadat Hosseini,Nasrin Gholami,Sheida Janati +8 more
TL;DR: In this article , the authors discuss the current status of combination therapy with nivolumab in cancer patients, with a particular focus on the recent clinical reports, and discuss the rationale of adding other conventional therapies such as chemo-radiotherapy and targeted therapies, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and VEGF/VEGFR inhibitors to nivilumab.
References
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Journal ArticleDOI
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
Elizabeth Eisenhauer,P. Therasse,Jan Bogaerts,Lawrence H. Schwartz,Daniel J. Sargent,Robert Ford,Janet Dancey,S. Arbuck,S. Gwyther,Margaret M. Mooney,Larry Rubinstein,Lalitha K. Shankar,Lori E. Dodd,Robert M. Kaplan,Denis Lacombe,Jaap Verweij +15 more
TL;DR: The revised RECIST includes a new imaging appendix with updated recommendations on the optimal anatomical assessment of lesions, and a section on detection of new lesions, including the interpretation of FDG-PET scan assessment is included.
Journal ArticleDOI
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TL;DR: Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.
Journal Article
[New response evaluation criteria in solid tumours-revised RECIST guideline (version 1.1)].
Hirokazu Watanabe,Morihito Okada,Yasushi Kaji,Miyako Satouchi,Yozo Sato,Yuichiro Yamabe,Hiroaki Onaya,Masahiro Endo,Miyuki Sone,Yasuaki Arai +9 more
TL;DR: This paper is an overview of the new response evaluation criteria in solid tumours: revised RECIST guideline (version 1. 1), with a focus on updated contents.
Journal ArticleDOI
Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria
Jedd D. Wolchok,Axel Hoos,Steven J. O'Day,Jeffrey S. Weber,Omid Hamid,Céleste Lebbé,Michele Maio,Michael Binder,Oliver Bohnsack,Geoffrey M. Nichol,R. Humphrey,F. Stephen Hodi +11 more
TL;DR: Systematic criteria, designated immune-related response criteria, were defined in an attempt to capture additional response patterns observed with immune therapy in advanced melanoma beyond those described by Response Evaluation Criteria in Solid Tumors or WHO criteria.
Summary of product characteristics
Helen Andrew,Gemma Gossedge,Julie Croft,Neil Corrigan,Julia Brown,Nicholas West,Philip Quirke,Damian Tolan,Ronan A. Cahill,David Jayne +9 more
TL;DR: Trimetazidine is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line antianginal therapies.
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