Journal ArticleDOI
Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999.
Jane Boydell,J. van Os,Avshalom Caspi,Noel Kennedy,E Giouroukou,Paul Fearon,Michael Farrell,Robin M. Murray +7 more
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TLDR
Cannabis use in the year prior to presentation with schizophrenia increased markedly between 1965 and 1999, and disproportionately so compared to increase in cannabis use in other psychiatric disorders.Abstract:
Background. There is evidence that cannabis use might be relevant to the aetiology of schizophrenia. We aimed to measure any change in cannabis use over time in those first presenting with schizophrenia in South-East London from 1965 to 1999, and compare this with change in use in those presenting with non-psychotic psychiatric disorders.Method. The rate of cannabis use in the year prior to first ever presentation was measured over seven time periods. Logistic regression modelling was used to determine (a) whether cannabis use changed over time, after controlling for age, sex and ethnicity, and (b) whether there was an interaction between diagnosis and time.Results. Cannabis use increased over time in both the schizophrenia group [odds ratio per time period (OR) 2·03, 95% confidence interval (CI) 1·74–2·38, p<0·0001] and the non-psychotic disorders group (OR 1·24, 95% CI 1·05–1·47, p=0·012), after controlling for age, sex and ethnicity. However, the effect of time was significantly greater in the schizophrenia group than in the non-schizophrenia group (χ2=17, p<0·0001).Conclusion. Cannabis use in the year prior to presentation with schizophrenia increased markedly between 1965 and 1999, and disproportionately so compared to increase in cannabis use in other psychiatric disorders.read more
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Adverse health effects of non-medical cannabis use
Wayne Hall,Louisa Degenhardt +1 more
TL;DR: The most probable adverse effects include a dependence syndrome, increased risk of motor vehicle crashes, impaired respiratory function, cardiovascular disease, and adverse effects of regular use on adolescent psychosocial development and mental health.
Journal ArticleDOI
The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study
Marta Di Forti,Marta Di Forti,Marta Di Forti,Diego Quattrone,Diego Quattrone,Diego Quattrone,Tom P. Freeman,Giada Tripoli,Charlotte Gayer-Anderson,Harriet Quigley,Victoria Rodriguez,Hannah E Jongsma,Hannah E Jongsma,Laura Ferraro,Caterina La Cascia,Daniele La Barbera,Ilaria Tarricone,Domenico Berardi,Andrei Szöke,Celso Arango,Andrea Tortelli,Eva Velthorst,Miguel Bernardo,Cristina Marta Del-Ben,Paulo Rossi Menezes,Jean-Paul Selten,Peter B. Jones,James B. Kirkbride,Bart P. F. Rutten,Lieuwe de Haan,Pak C. Sham,Pak C. Sham,Jim van Os,Jim van Os,Cathryn M. Lewis,Cathryn M. Lewis,Michael T. Lynskey,Craig Morgan,Robin M. Murray,Robin M. Murray,Silvia Amoretti,Manuel Arrojo,Grégoire Baudin,Stephanie Beards,Miquel Bernardo,Julio Bobes,Chiara Bonetto,Bibiana Cabrera,Angel Carracedo,Thomas Charpeaud,Javier Costas,Doriana Cristofalo,Pedro Cuadrado,Covadonga M. Díaz-Caneja,Aziz Ferchiou,Nathalie Franke,Flora Frijda,Enrique García Bernardo,Paz García-Portilla,Emiliano González,Kathryn Hubbard,Stéphane Jamain,Estela Jiménez-López,Marion Leboyer,Gonzalo López Montoya,Esther Lorente-Rovira,Camila Marcelino Loureiro,Giovanna Marrazzo,Covadonga Martínez,Mario de Matteis,Elles Messchaart,Ma Dolores Moltó,Juan Nacher,Ma Soledad Olmeda,Mara Parellada,Javier González Peñas,Baptiste Pignon,Marta Rapado,Jean Romain Richard,José Juan Rodríguez Solano,Laura Roldán Díaz,Mirella Ruggeri,Pilar A. Saiz,Emilio Sánchez,Julio Sanjuán,Crocettarachele Sartorio,Franck Schürhoff,F. Seminerio,Rosana Shuhama,Lucia Sideli,Simona A. Stilo,Fabian Termorshuizen,Sarah Tosato,Anne Marie Tronche,Daniella van Dam,Elsje van der Ven +95 more
TL;DR: Differences in frequency of daily cannabis use and in use of high-potency cannabis contributed to the striking variation in the incidence of psychotic disorder across the 11 studied sites, giving important implications for public health.
Journal ArticleDOI
What has research over the past two decades revealed about the adverse health effects of recreational cannabis use
TL;DR: The epidemiological literature in the past 20 years shows that cannabis use increases the risk of accidents and can produce dependence, and that there are consistent associations between regular cannabis use and poor psychosocial outcomes and mental health in adulthood.
Journal ArticleDOI
Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study.
Marta Di Forti,Arianna Marconi,Elena Carra,Sara Fraietta,Antonella Trotta,Matteo Bonomo,Francesca Bianconi,Poonam Gardner-Sood,Jennifer O'Connor,Manuela Russo,Simona A. Stilo,Tiago Reis Marques,Valeria Mondelli,Paola Dazzan,Carmine M. Pariante,Anthony S. David,Fiona Gaughran,Zerrin Atakan,Conrad Iyegbe,John Powell,Craig Morgan,Michael T. Lynskey,Robin M. Murray +22 more
TL;DR: The ready availability of high potency cannabis in south London might have resulted in a greater proportion of first onset psychosis cases being attributed to cannabis use than in previous studies.
Journal ArticleDOI
Incidence of Schizophrenia and Other Psychoses in England, 1950–2009: A Systematic Review and Meta-Analyses
James B. Kirkbride,Antonia Errazuriz,Tim Croudace,Craig Morgan,Dan Jackson,Jane Boydell,Robin M. Murray,Peter B. Jones +7 more
TL;DR: A systematic review of incidence rates in England over a sixty-year period found no evidence to support an overall change in the incidence of psychotic disorder over time, though diagnostic shifts (away from schizophrenia) were reported.
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Journal ArticleDOI
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