Open AccessJournal Article
Tumor necrosis factor: receptors and inhibitors.
Reads0
Chats0
TLDR
Tumor necrosis factor is a highly potent pleiotropic response modifier in inflammatory and immunologic host defense reactions and can also be toxic to cells and elicit toxic systemic reactions, as evinced by certain pathophysiologic conditions that are initiated or aggravated by an excess of TNF.About:
This article is published in Cancer Cell.The article was published on 1991-06-01 and is currently open access. It has received 97 citations till now. The article focuses on the topics: B-cell activating factor & Tumor necrosis factor alpha.read more
Citations
More filters
Journal ArticleDOI
TNF alpha and the TNF receptor superfamily: structure-function relationship(s).
TL;DR: The structure/function relationships of the TNFα and the T NF receptor superfamily are reviewed and insights as to how structural features play a role in the pleiotropic effects of TNF α are discussed.
Journal ArticleDOI
Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55.
TL;DR: The predominant role of TNF-R55 in T NF-alpha-induced adhesion in HUVEC may correlate with its specific control of NF-kappa B activation, since kappa B elements are known to be present in ICAM-1, E-selectin, and VCAM- 1 gene regulatory sequences.
Journal ArticleDOI
The potential biological and clinical significance of the soluble tumor necrosis factor receptors
TL;DR: The role of TNF receptors (TNF-Rs) is not limited to signal transduction but includes extracellular regulatory functions affecting systemic TNF bioavailability and the potential diagnostic, prognostic and therapeutic value of the soluble receptors in malignant, inflammatory, infectious and autoimmune disorders is summarized.
Journal ArticleDOI
Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice
P F Piguet,C Vesin +1 more
TL;DR: It is suggested that rsTNFR-beta might be useful in the therapy of pulmonary fibrosis and reduced the proportion of areas of damaged lung and, in silicosis, the formation of nodules with a rich collagen content.
Journal ArticleDOI
Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not.
Rudi Beyaert,Walter Fiers +1 more
TL;DR: TNF‐induced post‐receptor signaling mechanisms which seem to be involved in the pathway to cytotoxicity are reviewed.