UK guidelines on the management of iron deficiency in pregnancy.
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In this paper, a guideline for the diagnosis, treatment and prevention of iron deficiency in pregnancy and the postpartum period is presented, which is the first such guideline in the UK and may be applicable to other developed countries.Abstract:
Iron deficiency is the most common deficiency state in the world, affecting more than 2 billion people globally. Although it is particularly prevalent in less-developed countries, it remains a significant problem in the developed world, even where other forms of malnutrition have already been almost eliminated. Effective management is needed to prevent adverse maternal and pregnancy outcomes, including the need for red cell transfusion. The objective of this guideline is to provide healthcare professionals with clear and simple recommendations for the diagnosis, treatment and prevention of iron deficiency in pregnancy and the postpartum period. This is the first such guideline in the UK and may be applicable to other developed countries. Public health measures, such as helminth control and iron fortification of foods, which can be important to developing countries, are not considered here. The guidance may not be appropriate to all patients and individual patient circumstances may dictate an alternative approach.read more
Citations
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Journal ArticleDOI
Iron-deficiency anemia.
TL;DR: A review of the global nature of the disease, iron homeostasis in normal and iron-deficient states, clinical findings, treatment, and causes of iron-resistant iron deficiency is given in this article.
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Ferrous Sulfate Supplementation Causes Significant Gastrointestinal Side-Effects in Adults: A Systematic Review and Meta-Analysis
TL;DR: The meta-analysis confirms that ferrous sulfate is associated with a significant increase in gastrointestinal-specific side-effects but does not find a relationship with dose.
Journal Article
Iron requirements in pregnancy and strategies to meet them. Discussion
T. H. Bothwell,Martorell +1 more
TL;DR: In the first trimester of pregnancy, a reduction in iron absorption is followed by a progressive rise in absorption throughout the remainder of pregnancy as mentioned in this paper, which is the same as in non-pregnant women.
Journal ArticleDOI
Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management.
David S. Rampton,Joergen Folkersen,Steven Fishbane,Michael Hedenus,Stefanie Howaldt,Francesco Locatelli,Shalini Patni,Janos Szebeni,Guenter Weiss +8 more
TL;DR: Complement activation-related pseudo-allergy triggered by iron nanoparticles is probably a more frequent pathogenetic mechanism in acute reactions to current formulations of intravenous iron than is an immunological IgE-mediated response.
Journal ArticleDOI
Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review
TL;DR: It appears that for the diagnosis of ID, a cutoff of 100 μg/L for serum ferritin concentration should be considered in most conditions and 20% for TSAT, except in particular situations, including young healthy women with heavy menstrual flow.
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