Journal ArticleDOI
Ultrastructural evaluation of acute nasal toxicity in the rat respiratory epithelium in response to formaldehyde gas.
TLDR
Results demonstrate that short-term exposure to 6 or 15 ppm of HCHO caused respiratory epithelial injury which was not cell specific, but was dose related in severity.About:
This article is published in Toxicological Sciences.The article was published on 1986-02-01. It has received 34 citations till now. The article focuses on the topics: Respiratory epithelium.read more
Citations
More filters
Journal ArticleDOI
Formaldehyde Toxicity—New Understanding
TL;DR: The sources, modes, and levels of exposure to human populations, reproductive, behavioral, and neurotoxic effects, dermal effects, and most of the earlier data pertaining to its genotoxicity are revealed.
Journal ArticleDOI
The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity.
TL;DR: Biological evidence suggests that there is no delivery of inhaled formaldehyde to distant sites, and that multiple inhalation bioassays have not induced leukemia in animals, and the negative findings provide convincing evidence that formaldehyde is not leukemogenic.
Journal ArticleDOI
Inhaled Formaldehyde: Exposure Estimation, Hazard Characterization, and Exposure-Response Analysis
R G Liteplo,M. E. Meek +1 more
TL;DR: Risks of respiratory-tract cancers for the general population estimated on the basis of a biologically motivated case-specific model are exceedingly low, based primarily upon data derived from laboratory studies.
Journal ArticleDOI
Experimental toxicology of formaldehyde
TL;DR: Data on formaldehyde-DNA interaction further support the argument that a direct risk extrapolation from the formaldehyde effects in rats to those expected for man is not possible.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This summary of public comments on the draft Preamble to the IARC Monographs will be considered by the Advisory Group that will meet in December 2005 to review the amended Preambling.
References
More filters
Journal ArticleDOI
Reconstructions of Centriole Formation and Ciliogenesis in Mammalian Lungs
TL;DR: Reconstruction of the processes of centriolar formation and ciliogenesis based on evidence found in electron micrographs of tissues and organ cultures obtained chiefly from the lungs of foetal rats leads to an interpretation of the centriole as a semi-autonomous organelle whose replicative capacity is separable from the characteristic triplet fibre structure of its wall.
Journal Article
Carcinogenicity of Formaldehyde in Rats and Mice after Long-Term Inhalation Exposure
TL;DR: Rhinitis, epithelial dysplasia, and squamous metaplasia occurred in all exposure groups of rats and in the intermediate and high exposure groups in mice, and formaldehyde inhalation was weakly associated with an increase in the frequency of polypoid adenomas in the nasal cavity of male rats.
Journal Article
Induction of Squamous Cell Carcinomas of the Rat Nasal Cavity by Inhalation Exposure to Formaldehyde Vapor
TL;DR: Rinitis, epithelial dysplasia, and squamous metaplasia occurred in rats from all exposure levels of formaldehyde; however, the severity and extent of the lesions were dose related.
Journal ArticleDOI
The respiratory epithelium. IV. Histogenesis of epidermoid metaplasia and carcinoma in situ in the hamster.
TL;DR: The conclusion is that epidermoid metaplasia and carcinoma in situ can result from conversion of mucous cells, which implies the direct transformation of one type of fully differentiated cell to another.