Journal ArticleDOI
Uncertainty of the time of first significance in random effects cumulative meta-analysis.
TLDR
These simulated meta-analyses demonstrate the main point, which is that the time of first significance, however parameterized, is itself a random variable with error variance.About:
This article is published in Controlled Clinical Trials.The article was published on 1996-10-01. It has received 81 citations till now. The article focuses on the topics: Confidence interval & Random effects model.read more
Citations
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Journal ArticleDOI
Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis.
TL;DR: TSA may establish when firm evidence is reached in meta-analysis, and six randomly selected neonatal meta-analyses showed early potentially spurious P<0.05 values, establishing firm evidence of an intervention effect.
Journal ArticleDOI
Apparently conclusive meta-analyses may be inconclusive—Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
TL;DR: A trial sequential analysis (TSA) may reduce risk of random errors due to repetitive testing of accumulating data by evaluating meta-analyses not reaching the information size with monitoring boundaries, analogous to sequential monitoring boundaries in a single trial.
Journal ArticleDOI
Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?
Kristian Thorlund,Philip J. Devereaux,Jørn Wetterslev,Gordon H. Guyatt,John P. A. Ioannidis,Lehana Thabane,Lise Lotte Gluud,Bodil Als-Nielsen,Christian Gluud +8 more
TL;DR: Evaluating statistical inference with trial sequential monitoring boundaries when meta-analyses fall short of a required IS may reduce the risk of false positive results and important inaccurate effect estimates.
Journal ArticleDOI
Trial Sequential Analysis in systematic reviews with meta-analysis
TL;DR: Trial Sequential Analysis represents analysis of meta-analytic data, with transparent assumptions, and better control of type I and type II errors than the traditional meta-analysis using naïve unadjusted confidence intervals.
Journal ArticleDOI
Psychological therapies for people with borderline personality disorder
TL;DR: Assessment of the effects of psychological interventions for borderline personality disorder (BPD) found moderate to large statistically significant effects indicating a beneficial effect of DBT over TAU for anger.
References
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Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Beta blockade during and after myocardial infarction: an overview of the randomized trials
TL;DR: The aim has been not only to review the 65-odd randomized beta blocker trials but also to demonstrate that when many randomized trials have all applied one general approach to treatment, it is often not appropriate to base inference on individual trial results.
Journal ArticleDOI
A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction.
TL;DR: Finding and analyzing all therapeutic trials in a given field has become such a difficult and specialized task that the clinical experts called on to summarize the evidence in a timely fashion need access to better databases and new statistical techniques to assist them.
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Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction
Joseph Lau,Elliott M. Antman,Jeanette Jimenez-Silva,Bruce Kupelnick,Frederick Mosteller,Thomas C. Chalmers +5 more
TL;DR: Cumulative meta-analysis of therapeutic trials facilitates the determination of clinical efficacy and harm and may be helpful in tracking trials, planning future trials, and making clinical recommendations for therapy.