Understanding the Impacts of Bacteriophage Viruses: From Laboratory Evolution to Natural Ecosystems.
TLDR
The myriad ways that phages shape and are themselves shaped by bacterial host populations and communities are explored, with a particular focus on observed and predicted differences between the laboratory and complex microbial communities.Abstract:
Viruses of bacteriophages (phages) have broad effects on bacterial ecology and evolution in nature that mediate microbial interactions, shape bacterial diversity, and influence nutrient cycling and ecosystem function. The unrelenting impact of phages within the microbial realm is the result, in large part, of their ability to rapidly evolve in response to bacterial host dynamics. The knowledge gained from laboratory systems, typically using pairwise interactions between single-host and single-phage systems, has made clear that phages coevolve with their bacterial hosts rapidly, somewhat predictably, and primarily by counteradapting to host resistance. Recent advancement in metagenomics approaches, as well as a shifting focus toward natural microbial communities and host-associated microbiomes, is beginning to uncover the full picture of phage evolution and ecology within more complex settings. As these data reach their full potential, it will be critical to ask when and how insights gained from studies of phage evolution in vitro can be meaningfully applied to understanding bacteria-phage interactions in nature. In this review, we explore the myriad ways that phages shape and are themselves shaped by bacterial host populations and communities, with a particular focus on observed and predicted differences between the laboratory and complex microbial communities. Expected final online publication date for the Annual Review of Virology, Volume 9 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.read more
Citations
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Multispecies biofilm architecture determines bacterial exposure to phages
TL;DR: In this paper , the authors study how the cellular scale architecture of model 2-species biofilms impacts cell-cell and cell-phage interactions controlling larger scale population and community dynamics.
Journal ArticleDOI
Multispecies biofilm architecture determines bacterial exposure to phages
TL;DR: In this paper , the authors study how the cellular scale architecture of model 2-species biofilms impacts cell-cell and cell-phage interactions controlling larger scale population and community dynamics.
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Understanding Bacteriophage Tail Fiber Interaction with Host Surface Receptor: The Key “Blueprint” for Reprogramming Phage Host Range
Jarin Taslem Mourosi,Ayobami Awe,Wenzheng Guo,Himanshu Batra,Harrish Ganesh,Xiaorong Wu,Jingen Zhu +6 more
TL;DR: The molecular mechanisms and models of the tail fibers of the well-characterized T4 phage’s interaction with host surface receptors are discussed, including machine-learning-assisted engineering inspired by the increasingly enormous amount of phage genetic information.
Posted ContentDOI
Persistent lytic bacteriophage infection as a novel strategy for exploitation of nutrient-limited host bacteria
TL;DR: In this paper , the authors demonstrate that a virulent bacteriophage SPP1 productively infects nutrient-limited stationary phase cultures of the Gram-positive bacterium Bacillus subtilis.
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The Burden of Survivors: How Can Phage Infection Impact Non-Infected Bacteria?
TL;DR: The reaction of such systems to viral infection is likely to go beyond each cell or species tackling the phage attack independently as mentioned in this paper , and may also influence the physiological state and/or phenotypic features of those cells that have not yet had direct contact with the virus or are even intrinsically unable to become infected by the particular virus.
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