Urinary tract infections: disease panorama and challenges.
Walter E. Stamm,S. Ragnar Norrby +1 more
TLDR
An overview of the etiology and epidemiology of UTI, diagnostic and therapeutic approaches, current management strategies, evolution of antimicrobial resistance, and current approaches to prevention is provided.Abstract:
The major goal of this conference was to review new advances in our undertaking of the pathogenesis of urinary tract infections (UTIs) from the perspective of both the pathogen and the host. This initial presentation provided an appropriate context for subsequent discussion by providing an overview of the etiology and epidemiology of UTI, diagnostic and therapeutic approaches, current management strategies, evolution of antimicrobial resistance, and current approaches to prevention.read more
Citations
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Journal ArticleDOI
Urinary tract infections: epidemiology, mechanisms of infection and treatment options
TL;DR: How basic science studies are elucidating the molecular details of the crosstalk that occurs at the host–pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs is discussed.
Journal ArticleDOI
Trends in Antimicrobial Resistance among Urinary Tract Infection Isolates of Escherichia coli from Female Outpatients in the United States
TL;DR: National resistance rates to SXT were relatively consistent but demonstrated considerable regional and institutional variation in 2001, and Therapies other than SXT may need to be considered in some locations.
Journal ArticleDOI
How to become a uropathogen: Comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains
Elzbieta Brzuszkiewicz,Holger Brüggemann,Heiko Liesegang,Melanie Emmerth,Tobias Ölschläger,Gábor Nagy,Kaj Albermann,Christian Wagner,Carmen Buchrieser,Levente Emödy,Gerhard Gottschalk,Jörg Hacker,Ulrich Dobrindt +12 more
TL;DR: Analysis of virulence-associated traits expressed in the two UPEC O6 strains, together with genome comparison, demonstrate the marked genetic and phenotypic variability among UPEC.
Journal ArticleDOI
Risk factors for ciprofloxacin resistance among Escherichia coli strains isolated from community-acquired urinary tract infections in Turkey
TL;DR: The increasing prevalence of infections caused by antibiotic-resistant bacteria makes the empirical treatment of UTIs more difficult, and fluoroquinolone-sparing agents such as nitrofurantoin and fosfomycin should be evaluated as alternative therapies by further clinical efficacy and safety studies.
Journal ArticleDOI
The emerging threat of multidrug-resistant Gram-negative bacteria in urology
Hosam M. Zowawi,Patrick N A Harris,Matthew J. Roberts,Paul A. Tambyah,Mark A. Schembri,M. Diletta Pezzani,Deborah A Williamson,David L. Paterson +7 more
TL;DR: Responding to the challenges of Gram-negative resistance will require a multifaceted approach including considered use of current antimicrobial agents, improved diagnostics and surveillance, better adherence to basic measures of infection prevention, development of new antibiotics and research into non-antibiotic treatment and preventive strategies.
References
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Journal ArticleDOI
Urinary tract infection: self-reported incidence and associated costs.
TL;DR: In this paper, the authors estimate that by age 24, one-third of women will have at least one physician-diagnosed UTI that was treated with prescription medication, and the annual cost of UTI cases with prescriptions to be $1.6 billion in 1995.
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Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women
John W. Warren,Elias Abrutyn,J. Richard Hebel,James R. Johnson,Anthony J. Schaeffer,Walter E. Stamm +5 more
TL;DR: This guideline is to provide assistance to clinicians in the diagnosis and treatment of two specific types of urinary tract infections (UTIs): uncomplicated, acute, symptomatic bacterial cystitis and acute pyelonephritis in women.
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Urinary Tract Infection
TL;DR: If a vaccine were developed that would prevent either initial or recurrent UTI the net benefits to society would be substantial, even at a developmental cost of one billion dollars.
Journal ArticleDOI
A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections
Raul Raz,Walter E. Stamm +1 more
TL;DR: The intravaginal administration of estriol prevents recurrent urinary tract infection in postmenopausal women, probably by modifying the vaginal flora.