Journal ArticleDOI
Vaccination against Louping Ill Virus Protects Goats from Experimental Challenge with Spanish Goat Encephalitis Virus.
L. M. Salinas,Rosa Casais,J.F. García Marín,Kevin P. Dalton,Luis J. Royo,A. del Cerro,E. Gayo,Mark P. Dagleish,Pilar Alberdi,Ramón A. Juste,J. de la Fuente,Ana Balseiro +11 more
TLDR
Vaccination of goats against LIV confers highly effective protection against SGEV; this is probably mediated by IgG and prevents an increase in viral RNA load in serum such that vaccinated animals would not be an effective reservoir of the virus.About:
This article is published in Journal of Comparative Pathology.The article was published on 2017-05-01. It has received 11 citations till now. The article focuses on the topics: Encephalitis.read more
Citations
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Targeting a global health problem: Vaccine design and challenges for the control of tick-borne diseases.
TL;DR: The potential of vaccines for the control of TBDs has been underestimated due to major challenges to reduce tick infestations, pathogen infection, multiplication and transmission, tick attachment and feeding time and/or host Pathogen infection.
Journal ArticleDOI
Lambs are Susceptible to Experimental Challenge with Spanish Goat Encephalitis Virus.
L. M. Salinas,Rosa Casais,J.F. García Marín,Kevin P. Dalton,Luis J. Royo,A. del Cerro,E. Gayo,Mark P. Dagleish,Ramón A. Juste,Ana Balseiro +9 more
TL;DR: The results show that SGEV can infect sheep by both the subcutaneous and intravenous routes, resulting in neurological clinical disease with extensive and severe histological lesions in the central nervous system.
Journal ArticleDOI
120 years of Louping-ill Research: an Historical Perspective from the Archive of the Journal of Comparative Pathology.
TL;DR: A selection of articles on research into louping-ill published in the Journal of Comparative Pathology and its earlier title highlights the sometimes daunting task of trying to unravel such a complex set of disease circumstances and how understanding was achieved.
Journal ArticleDOI
Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats
Kristi L. Helke,David K. Meyerholz,Amanda P. Beck,Eric R. Burrough,Rachel J. Derscheid,Christiane V. Löhr,Elizabeth F. McInnes,Cheryl L. Scudamore,Cory Brayton +8 more
TL;DR: In this paper, a review of animal model features can be found in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats.
Journal ArticleDOI
Phenotypic characterization of encephalitis in the brains of goats experimentally infected with Spanish Goat Encephalitis Virus.
Ileana Z. Martínez,Ileana Z. Martínez,Claudia Pérez-Martínez,L. M. Salinas,J. F. García-Marín,Ramón A. Juste,Ana Balseiro +6 more
TL;DR: Results suggest that the cellular immune response would be the most important response to the SGEV infection, and that medulla oblongata and spinal cord were the most affected tissues.
References
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Journal ArticleDOI
Tick-borne encephalitis
TL;DR: The clinical manifestations associated with TBEV infections, the main molecular-biological properties of these viruses, and the different factors that define the incidence and severity of disease are described.
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B Cells and Antibody Play Critical Roles in the Immediate Defense of Disseminated Infection by West Nile Encephalitis Virus
TL;DR: It is concluded that antibodies and B cells play a critical early role in the defense against disseminated infection by WNV and Passive transfer of heat-inactivated serum from infected and immune wild-type mice protected μMT mice against morbidity and mortality.
Journal ArticleDOI
The pathology and pathogenesis of bluetongue.
TL;DR: Bluetongue (BT) is an insect-transmitted viral disease of wild and domestic ruminants and, occasionally, other species, and amongst domestic livestock, BT is most common in certain breeds of sheep whereas asymptomatic BT virus (BTV) infection of cattle is typical in enzootic regions.
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Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy.
Gilda Grard,Gregory Moureau,Rémi N. Charrel,Jean-Jacques Lemasson,Jean-Paul Gonzalez,Pierre Gallian,T.S. Gritsun,Edward C. Holmes,Ernest A. Gould,Xavier de Lamballerie +9 more
TL;DR: Analysis of coding sequences of all recognized tick-borne flavivirus species suggest a complex relationship between viruses infecting birds and those infecting mammals and ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages.
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Invasion and Intracellular Development of the Human Granulocytic Ehrlichiosis Agent in Tick Cell Culture
Ulrike G. Munderloh,Steven D. Jauron,Volker Fingerle,Lorenz Leitritz,S. Fred Hayes,Joan M. Hautman,Curtis M. Nelson,Brent W. Huberty,Timothy J. Kurtti,Gilbert G. Ahlstrand,Barbara Greig,Martha A. Mellencamp,Jesse L. Goodman +12 more
TL;DR: It is proved that the blood stages of the HGE agent are infectious for tick cells, as are those replicating in the human cell line HL60, proving that the cycle of replication and development in the vector is prerequisite to mammalian infection.