Open AccessJournal Article
Value of Combined Detection of Serum CEA, CA72-4, CA19-9, CA15-3 and CA12-5 in the Diagnosis of Gastric Cancer.
TLDR
The combined detection of serum CA72–4, CEA, CA19–9 and CA12–5 increases the sensitivity and accuracy in the diagnosis of GC and can thus be considered an important tool for early diagnosis.Abstract:
Background To examine whether the combined detection of serum tumor markers (CEA, CA72-4, CA19-9, CA15-3 and CA12-5) improves the sensitivity and accuracy in the diagnosis of gastric cancer (GC). Materials and methods An automatic chemiluminescence immune analyzer with matched kits was used to determine the levels of serum CEA, CA72-4, CA19-9, CA15-3, and CA12-5 in 87 patients with gastric cancer (GC group), 60 patients with gastric benign diseases (GBD group) who were hospitalized during the same period, and 40 healthy subjects undergoing a physical examination. The values of these 5 tumor markers in the diagnosis of gastric cancer were analyzed. Results The levels of serum CEA, CA72-4, CA19-9, and CA12-5 were higher in the GC group than in the GBD group and healthy subjects, and these differences were significant (P 0.05). The combined detection of CEA, CA72-4, CA19-9, and CA12-5 had a higher diagnostic value for gastric cancer than did single detection, and the positive detection rate of the combined detection of the four tumor markers was 60.9%. The diagnostic power when using the combined detection of CA72-4, CEA, CA19-9, and CA12-5 was the best. Conclusions The combined detection of serum CA72-4, CEA, CA19-9 and CA12-5 increases the sensitivity and accuracy in the diagnosis of GC and can thus be considered an important tool for early diagnosis.read more
Citations
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Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies.
TL;DR: Early-onset gastric cancer is a good model to study genetic alterations related to the carcinogenesis process, as young patients are less exposed to environmental carcinogens.
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Circulating Exosomal Gastric Cancer-Associated Long Noncoding RNA1 as a Biomarker for Early Detection and Monitoring Progression of Gastric Cancer: A Multiphase Study.
Xin Guo,Xiaohui Lv,Yi Ru,Fuxing Zhou,Wang Ning,Hongqing Xi,Kecheng Zhang,Jiyang Li,Rongyan Chang,Tianyu Xie,Xinxin Wang,Baohai Li,Yong Chen,Yanling Yang,Lubin Chen,Lin Chen +15 more
TL;DR: For patients with gastric cancer, detection of circulating exosomal lncRNA-GC1 may improve the early diagnostic rate and monitor disease progression.
Journal ArticleDOI
Prognostic Nutritional Index as a Predictor of Survival in Resectable Gastric Cancer Patients With Normal Preoperative Serum Carcinoembryonic Antigen Levels: A Propensity Score Matching Analysis
Noriyuki Hirahara,Yoshitsugu Tajima,Yusuke Fujii,Shunsuke Kaji,Tetsu Yamamoto,Ryoji Hyakudomi,Takahito Taniura,Yasunari Kawabata +7 more
TL;DR: It is demonstrated that a low preoperative PNI value is a potential independent risk factor for poorer CSS in patients with gastric cancer, even in those with normal preoperative serum CEA levels.
Book ChapterDOI
Serum CA153 as biomarker for cancer and noncancer diseases.
Xiulian Li,Yan Xu,Lijuan Zhang +2 more
TL;DR: It is proposed that the increased serum CA153 levels might be associated with pathological leakage of the epithelial cell product into the blood circulation in addition to the decreased CA153 clearance rate.
Journal ArticleDOI
Controlling Nutritional Status (CONUT) as a prognostic immunonutritional biomarker for gastric cancer after curative gastrectomy: a propensity score-matched analysis.
Noriyuki Hirahara,Yoshitsugu Tajima,Yusuke Fujii,Shunsuke Kaji,Yasunari Kawabata,Ryoji Hyakudomi,Tetsu Yamamoto,Takahito Taniura +7 more
TL;DR: It is advantageous to use both CEA level and the CONUT score to assess the prognosis of patients with gastric cancer, which reflect both tumor- related factors and host-related factors, respectively.
References
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Journal ArticleDOI
Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association
TL;DR: Although no prospective trial has yet been completed to evaluate the clinical significance of these serum markers, this literature survey suggests that combinations of CEA, CA19-9, and CA72-4 are the most effective ways for staging before surgery or chemotherapy.
Journal ArticleDOI
Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?
Cecília Durães,Gabriela M. Almeida,Raquel Seruca,Raquel Seruca,Carla Oliveira,Carla Oliveira,Fátima Carneiro,Fátima Carneiro +7 more
TL;DR: Clinical approaches based on the combination of correct staging with targeted and conventional systemic therapies may improve gastric cancer patients’ outcome, but are only in their infancy.
Journal ArticleDOI
Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer
TL;DR: The determination and application of optimal cut-off values based on ROC curve and logistic regression analysis could improve the diagnosis of gastric cancer based on common tumor markers.
Journal Article
Multivariate analysis of the prognostic value of CEA and CA 19-9 serum levels in colorectal cancer.
TL;DR: CEA and CA 19-9 can be used to discriminate two groups of patients with significantly different survival times, and the postoperative Dukes' classification represents the best prognostic information besides the preoperative values of CA19-9.
Journal ArticleDOI
Clinical significance and prognostic value of CA72-4 compared with CEA and CA19-9 in patients with gastric cancer.
TL;DR: It is suggested that the addition of CA 72-4 to CEA and/or CA 19-9 could improve sensitivity in gastric cancer and its usefulness in the monitoring of Gastric cancer should be taken into account.