Journal ArticleDOI
Vascular Endothelial Growth Factor and Angiogenesis
Ann Hoeben,Bart Landuyt,Martin Highley,Hans Wildiers,Allan T. van Oosterom,Ernst A. de Bruijn +5 more
TLDR
The role of V EGF in physiological and pathological processes is reviewed and how modulation of VEGF expression creates new therapeutic possibilities is discussed.Abstract:
Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro- and antiangiogenic molecules have already been discovered. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for endothelial cells. Signal transduction involves binding to tyrosine kinase receptors and results in endothelial cell proliferation, migration, and new vessel formation. In this article, the role of VEGF in physiological and pathological processes is reviewed. We also discuss how modulation of VEGF expression creates new therapeutic possibilities and describe recent developments in this field.read more
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Book ChapterDOI
The Metabolic Syndrome
TL;DR: The National Cholesterol Education Program’s Adult Treatment Panel III (ATP III) report added the metabolic syndrome, a multidimensional risk factor for cardiovascular disease (CVD), as a coequal partner of elevated low-density lipoprotein (LDL) cholesterol for risk-reduction therapies.
Journal ArticleDOI
Crossing the endothelial barrier during metastasis
TL;DR: How cancer cells cross the endothelial barrier during extravasation is described and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process are described.
Journal ArticleDOI
Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF).
TL;DR: VEGF plays a multifunctional role where it can also have autocrine pro‐survival effects and contribute to tumour cell chemoresistance and the therapeutic implications of targeting angiogenesis and VEGF receptors, particularly in cancer therapy.
Journal ArticleDOI
Vascular endothelial growth factor (VEGF) signaling in tumor progression
TL;DR: Owing to the importance of angiogenesis in tumor progression, inhibition of VEGF signaling represents an attractive cancer treatment.
Journal Article
Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis.
Carmen Stanca Melincovici,Adina Bianca Boşca,Sergiu Susman,Mariana Mărginean,Carina Mihu,Mihnea Istrate,Ioana Maria Moldovan,Alexandra Roman,Carmen Mihaela Mihu +8 more
TL;DR: This article aims to highlight the most recent data referring to the VEGF family and its receptors, as well as its implications in the angiogenesis process.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TL;DR: The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute.
Journal ArticleDOI
The Bcl-2 Protein Family: Arbiters of Cell Survival
Jerry M. Adams,Suzanne Cory +1 more
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