Vascular endothelial growth factor attenuates hepatic sinusoidal capillarization in thioacetamide-induced cirrhotic rats.
TLDR
Injection of a plasmid encoding VEGF through the portal vein is an effective method to induce the formation of fenestrae and decrease portal vein pressure in cirrhotic rats and may be a good choice for treating hepatic cirrhosis and portal hypertension.Abstract:
Vascular endothelial growth factor attenuates hepatic sinusoidal capillarization in thioacetamide-induced cirrhotic ratsread more
Citations
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Journal ArticleDOI
Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier.
Simon C. Satchell,Filip Braet +1 more
TL;DR: The structure-function relationships of GEnC fenestrations will be evaluated in depth, their role in health and disease explored, and the outlook for future study and therapeutic implications of these peculiar structures will be approached.
Journal ArticleDOI
Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats.
TL;DR: Sorafenib administered orally once a day for 2 weeks in experimental models of portal hypertension and cirrhosis effectively inhibited VEGF, PDGF, and Raf signaling pathways, and produced several protective effects by inducing an approximately 80% decrease in splanchnic neovascularization and a marked attenuation of hyperdynamic splan Schnic and systemic circulations.
Journal ArticleDOI
Mesenchymal stem cells support hepatocyte function in engineered liver grafts
Yoshie Kadota,Hiroshi Yagi,Kenta Inomata,Kentaro Matsubara,Taizo Hibi,Yuta Abe,Minoru Kitago,Masahiro Shinoda,Hideaki Obara,Osamu Itano,Yuko Kitagawa +10 more
TL;DR: Enhanced hepatic function was achieved using a strategy of sequential infusion of cells and the advantages of co-cultivating bone marrow-derived MSCs with primary hepatocytes in the engineered whole-liver scaffold were illustrated.
Journal Article
Vascular endothelial growth factor (VEGF) — part 2: in endocrinology and oncology
TL;DR: Endocrine glands are well vascularised and the structure of their vessels facilitates the exchange of various substances, including hormones, which are a frequent experimental model in research on VEGF and angiogenesis.
Journal ArticleDOI
Hematopoietic stem cells and liver regeneration: differentially acting hematopoietic stem cell mobilization agents reverse induced chronic liver injury.
Eleftheria Tsolaki,Evangelia Athanasiou,Eleni Gounari,Nikolaos Zogas,Eleni Siotou,Minas Yiangou,Achilles Anagnostopoulos,Evangelia Yannaki +7 more
TL;DR: The data suggest that G- CSF, Plerixafor and G-CSF+Plerixa for act differentially during the wound healing process, ultimately providing a potent anti-fibrotic effect.
References
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Book ChapterDOI
Preparation of isolated rat liver cells.
TL;DR: This chapter discusses preparation of isolated rat liver cells by incubation of rat liver minces with pronase, which results in most of the liver parenchyma is digested, while nonparenchymal cells remain intact and can be recovered from the incubate.
Journal ArticleDOI
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
W.G. Roberts,G E Palade +1 more
TL;DR: The VEGF effect on permeability is unlike that of any other mediator described to date since both muscular venules and capillaries are affected.
Journal ArticleDOI
Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review
Filip Braet,Eddie Wisse +1 more
TL;DR: This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae regarding their structure, origin, species specificity, dynamics and formation.
Journal ArticleDOI
An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids
TL;DR: The connection of the fenestrated lining to a certain type of cell present in the sinusoidal lining can be used to identify this cell as an endothelial cell, a new contribution to the morphological distinction between endothelial and Kupffer cells.
Journal ArticleDOI
Vascular endothelial growth factor induces endothelial fenestrations in vitro.
Sybille Esser,Karen Wolburg,Hartwig Wolburg,Georg Breier,Teymuras V. Kurzchalia,Werner Risau +5 more
TL;DR: This defined in vitro system will allow further study of the signaling mechanisms involved in fenestrae formation, modification of caveolae, and vascular permeability and concludes that VEGF in the presence of a basal lamina-type extracellular matrix specifically induces fenESTrations in endothelial cells.