Journal ArticleDOI
Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: Relation to pathogenesis of catecholamine cardiomyopathy
TLDR
The effects of adrenochrome and other metabolites of epinephrine on the ultrastructure and contractile activity of isolated rat hearts perfused under conditions in which the heart rate and coronary flow were controlled are examined to show consistency with the concept that oxidation products of catecholamines such as Adrenochrome are partly responsible for inducing myocardial necrosis and failure following massive catechlamine injections in intact animals.About:
This article is published in American Heart Journal.The article was published on 1981-08-01. It has received 139 citations till now. The article focuses on the topics: Adrenochrome & Epinephrine.read more
Citations
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Journal ArticleDOI
The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
Milton Packer,Michael R. Bristow,Jay N. Cohn,Wilson S. Colucci,Michael B. Fowler,Edward M. Gilbert,Neil H. Shusterman +6 more
TL;DR: Carvedilol reduces the risk or death as well as the risk of hospitalization for cardiovascular causes in patients with heart failure who are receiving treatment with digoxin, diuretics, and an angiotensin-converting-enzyme inhibitor.
Journal Article
The Effect of Carvedilol on Morbidity and Mortality in Patients With Chronic Heart Failure
Milton Packer,Michael R. Bristow,Jay N. Cohn,Wilson S. Colucci,Michael B. Fowler,Edward M. Gilbert,Neil H. Shusterman +6 more
TL;DR: In this paper, a double-blind, placebo-controlled, stratified program, in which patients were assigned to one of four treatment protocols on the basis of their exercise capacity, was presented.
Journal ArticleDOI
Role of oxidative stress in cardiovascular diseases.
TL;DR: The existing evidence support the view that oxidative stress may play a crucial role in cardiac and vascular abnormalities in different types of cardiovascular diseases and that the antioxidant therapy may prove beneficial in combating these problems.
Journal ArticleDOI
The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure.
TL;DR: Observations support the formulation of a neurohormonal hypothesis of heart failure and provide the basis for the development of novel therapeutic strategies in the next decade.
Journal ArticleDOI
Double-Blind, Placebo-Controlled Study of the Effects of Carvedilol in Patients With Moderate to Severe Heart Failure The PRECISE Trial
Milton Packer,Wilson S. Colucci,Jonathan Sackner-Bernstein,Chang Seng Liang,David A. Goldscher,Israel Freeman,Marrick L. Kukin,Vithal Kinhal,James E. Udelson,Marc Klapholz,Stephen S. Gottlieb,David L. Pearle,Robert J. Cody,John Gregory,Nikki E. Kantrowitz,Thierry H. LeJemtel,Sarah T. Young,Mary Ann Lukas,Neil H. Shusterman +18 more
TL;DR: In a multicenter trial as mentioned in this paper, patients with moderate to severe heart failure (6-minute walk distance, 150 to 450 m) and a left ventricular ejection fraction ≤ 0.35 at 31 centers were randomly assigned to either placebo or carvedilol for 6 months, while background therapy with digoxin, diuretics and an ACE inhibitor remained constant.
References
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Experimental Subendocardial Ischemia in Dogs with Normal Coronary Arteries
TL;DR: This study studied subendocardial ischemia without anatomic coronary artery obstruction in open-chest anesthetized dogs and measured pressures in aorta and left ventricle, phasic left coronary arterial blood flow by electromagnetic flowmeter and altered flow ratios were best predicted by relating them to the ratio of DPTI to TTI.
Journal Article
An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat.
Journal Article
Myocardial fiber necrosis due to intracellular Ca overload-a new principle in cardiac pathophysiology.
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The measurement of the cytochrome oxidase activity of enzyme preparations.
TL;DR: The enzyme and pectin solutions were submitted to dialysis against tap water and then distilled water, and the activity determined in the presence and absence of sodium chloride and sodium oxalate, which have been reported as being necessary for activation of the enzyme from tomatoes.