Journal ArticleDOI
Very low-dose fluvastatin-valsartan combination decreases parameters of inflammation and oxidative stress in patients with type 1 diabetes mellitus
TLDR
The approach consisting of short-term treatment with a very low-dose fluvastatin-valsartan combination acts anti-inflammatory and anti-oxidative in T1DM patients and the improvement of arterial function support the assumption that this approach could have an important clinical benefit in T 1DM patients.About:
This article is published in Diabetes Research and Clinical Practice.The article was published on 2017-05-01. It has received 7 citations till now. The article focuses on the topics: Valsartan & Diabetes mellitus.read more
Citations
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Journal ArticleDOI
The effects of statin use on inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.
Reza Tabrizi,Omid Reza Tamtaji,Naghmeh Mirhosseini,Kamran Bagheri Lankarani,Maryam Akbari,Ehsan Dadgostar,Afshin Borhani-Haghighi,Payam Peymani,Fariba Ahmadizar,Zatollah Asemi +9 more
TL;DR: The meta‐analysis showed beneficial effects of statin use on reducing inflammatory markers in patients with MetS and related disorders.
Journal ArticleDOI
Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension
Iuliia Polina,Mark Domondon,Rebecca Fox,Anastasia V. Sudarikova,Anastasia V. Sudarikova,Miguel Troncoso,Valeriia Y. Vasileva,Valeriia Y. Vasileva,Yuliia Kashyrina,Monika Gooz,Ryan Schibalski,Kristine Y. DeLeon-Pennell,Kristine Y. DeLeon-Pennell,Wayne R. Fitzgibbon,Daria V. Ilatovskaya +14 more
TL;DR: It is hypothesized here that increasing ANP level with sacubitril, combined with RAAS blockage by valsartan, can be beneficial for alleviation of renal damage in a model of SS hypertension, the Dahl SS rat.
Journal ArticleDOI
Prevention of Vascular Complications in Diabetes Mellitus Patients: Focus on the Arterial Wall.
TL;DR: If the pivotal role of vascular wall impairment in the pathogenesis and progression of microvascular and macrovascular complications is accepted, treatment focused directly on the arterial wall should be one of the priorities in prevention of vascular complications in patients with DM.
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Treating Arterial Ageing in Patients with Diabetes: From Mechanisms to Effective Drugs.
TL;DR: In this paper, the capacity of available drugs, particularly antidiabetic drugs, to interfere with the arterial ageing process was reviewed, and the three tightly connected cornerstone characteristics of arterial aging in patients with diabetes are: phenotypic presentation as endothelial dysfunction and arterial stiffness.
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Attenuating the Variability of Lipids Is Beneficial for the Hypertension Management to Reduce the Cardiovascular Morbidity and Mortality in Older Adults.
TL;DR: In this article, the authors investigated the beneficial of attenuating the variability of lipids to the hypertension management in older adults and found that rosuvastatin significantly attenuated the intra-visit variability in lipids and decreased the risk of cardiovascular mortality and morbidity.
References
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Journal ArticleDOI
Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients
Antonio Ceriello,Roberta Assaloni,Roberto Da Ros,Amabile Maier,Ludovica Piconi,Lisa Quagliaro,Katherine Esposito,Dario Giugliano +7 more
TL;DR: This study confirms an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial function and inflammation, suggesting oxidative stress as a common mediator of such an effect.
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Advanced Glycation End Products: A Molecular Target for Vascular Complications in Diabetes
TL;DR: Evidence supports AGEs’ involvement in diabetes- and aging-associated disorders such as diabetic vascular complications, cancer, Alzheimer’s disease and osteoporosis and inhibition of AGE formation could be a novel molecular target for organ protection in diabetes.
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Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus.
Alexander Riad,Jing Du,Sebastian Stiehl,Dirk Westermann,Zarah Mohr,Meike Sobirey,Wolfram Doehner,Volker Adams,Matthias Pauschinger,Heinz-Peter Schultheiss,Carsten Tschöpe +10 more
TL;DR: Lid-independent anti-oxidative and anti-inflammatory effects of low-dose atorvastatin involving the ERK1/2/NF-kappaB-pathway are sufficient to improve endothelial function under experimental diabetic conditions.
Journal ArticleDOI
Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism
TL;DR: Testing whether the protective effect of arginase inhibition is nitric oxide synthase-3 (eNOS)-dependent in diabetic nephropathy and has an eNOS-independent effect on kidney macrophage recruitment found it to be so.
Journal ArticleDOI
Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population.
TL;DR: Important areas remain to be addressed in the existing literature around CVD in T1D, particularly exploring the risks and benefits of therapeutic approaches to CVD management in the older aged.