Patent
Virus protein microarray and uses therefor
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TLDR
A virus protein micorarray that can serve as a rapid, sensitive and simple tool for identification of viral specific antibodies in sera, such as a SARS coronavirus protein microarray and methods of using the microarray.Abstract:
A virus protein micorarray that can serve as a rapid, sensitive and simple tool for identification of viral specific antibodies in sera, such as a SARS coronavirus protein microarray and methods of using the protein microarray.read more
Citations
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Immunoassay utilizing recombinant nucleocapsid-proteins for detection of antibodies to human coronaviruses
TL;DR: A coronavirus strain-specific line immunoassay based on recombinant nucleocapsid (N) proteins of all known pathogenic strains, which found that recently identified NL63 and HKU1 contribute significantly to the overall spectrum of coronav virus infections.
Patent
Methods and compositions for coronavirus diagnostics and therapeutics
TL;DR: In this paper, the authors presented methods and compositions for detecting a coronavirus in a sample and identifying the subgroup of the virus in the sample, and provided a method and composition for detecting and identifying subgroups of the Coronavirus.
References
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Journal ArticleDOI
Antibody responses to individual proteins of SARS coronavirus and their neutralization activities.
Maofeng Qiu,Yuling Shi,Zhaobiao Guo,Zeliang Chen,Rongqiao He,Runsheng Chen,Dongsheng Zhou,Erhei Dai,Xiaoyi Wang,Bingyin Si,Yajun Song,Jingxiang Li,Ling Yang,Jin Wang,Hongxia Wang,Xin Pang,Junhui Zhai,Zongmin Du,Ying Liu,Yong Zhang,Linhai Li,Jian Wang,Bing Sun,Ruifu Yang +23 more
TL;DR: It is suggested that anti-S and anti-N antibodies are diagnostic markers and in particular that S3 is immunogenic and therefore is a good candidate as a subunit vaccine antigen; and that, from a virus structure viewpoint, the presence in some human sera of antibodies reacting with two recombinant polypeptides, 3a and 9b, supports the hypothesis that they are synthesized during the virus cycle.
Journal ArticleDOI
Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray
Heng Zhu,Shaohui Hu,Ghil Jona,Xiaowei Zhu,Nate Kreiswirth,Barbara M. Willey,Tony Mazzulli,Guozhen Liu,Guozhen Liu,Qifeng Song,Peng Chen,Mark J. Cameron,Andrea D. Tyler,Jian Wang,Jie Wen,Weijun Chen,Susan R Compton,Michael Snyder +17 more
TL;DR: It is shown that protein microarrays can serve as a rapid, sensitive, and simple tool for large-scale identification of viral-specific antibodies in sera and demonstrated that viral infection can be monitored for many months after infection.
Journal ArticleDOI
Antigenicity Analysis of Different Regions of the Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein
Zeliang Chen,Decui Pei,Lingxiao Jiang,Yajun Song,Jin Wang,Hongxia Wang,Dongsheng Zhou,Junhui Zhai,Zongmin Du,Bei Li,Maofeng Qiu,Yanping Han,Zhaobiao Guo,Ruifu Yang +13 more
TL;DR: The N protein is a highly immunogenic protein of the SARS-CoV, and antigenicity of the COOH terminus is higher than that of the NH2 terminus.
Patent
Sars Virus Nucleotide and Amino Acid Sequences and Uses Thereof
Frank Plummer,Heinz Feldmann,Steven J.M. Jones,Yan Li,Nathalie Bastien,Robert Conrad Brunham,Angela Brooks-Wilson,Robert Holt,Christopher Upton,Rachel L. Roper,Caroline R. Astell +10 more
TL;DR: In this paper, the authors provided the genomic sequence of a putative coronavirus, the SARS virus, and provided novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS-related disorders.
Patent
Serum biomarkers for sars
TL;DR: In this article, the authors provided biomarkers and biomarker combinations that are useful in qualifying SARS status in a patient and provided diagnostic methodology employing these biomarkers, and combinations thereof that can distinguish between SARS and normal.