Journal ArticleDOI
Viruses Causing Common Respiratory Infection in Man. IV. Reoviruses and Adenoviruses
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This article is published in The Journal of Infectious Diseases.The article was published on 1973-12-01. It has received 61 citations till now. The article focuses on the topics: Respiratory infection & Respiratory tract infections.read more
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Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study.
Richard Simon,John F. Engelhardt,Yiping Yang,Monica Zepeda,Sara Weber-Pendleton,Mariann Grossman,James M. Wilson +6 more
TL;DR: It is concluded that adenovirus-mediated gene transfer into the lungs of baboons is associated with development of alveolar inflammation at high doses of virus.
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A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancer.
Laura Vidal,Hardev Pandha,Timothy A. Yap,C L White,K Twigger,Richard G. Vile,Richard G. Vile,Alan Melcher,Matthew C. Coffey,Kevin J. Harrington,J. De-Bono +10 more
TL;DR: Oncolytic reovirus can be safely and repeatedly administered by i.v. injection at doses up to 3 × 1010 TCID50 for 5 days every 4 weeks without evidence of severe toxicities, and is a safe agent that warrants further evaluation in phase II studies.
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Reovirus as a novel oncolytic agent
Kara L. Norman,Patrick W.K. Lee +1 more
TL;DR: Research using murine cancer models has revealed that this genetically unmodified laboratory strain of reovirus can indeed selectively destroy tumor cells, with no manifestations of animal morbidity or mortality, leading the way to investigation into its therapeutic potential in human cancer.
Journal ArticleDOI
Intravenous administration of Reolysin®, a live replication competent RNA virus is safe in patients with advanced solid tumors
Radharani Gollamudi,M. H. Ghalib,Kavita K. Desai,Imran Chaudhary,Benny Wong,Mark H. Einstein,Mark H. Einstein,Matthew C. Coffey,George M. Gill,K. Mettinger,John M. Mariadason,John M. Mariadason,Sridhar Mani,Sridhar Mani,Sanjay Goel,Sanjay Goel +15 more
TL;DR: Reolysin has anti-tumor activity as a single agent warranting further evaluation, including in combination with chemotherapy, and may suggest intrapatient replication yielding a benefit and should be studied carefully in future studies.
Journal ArticleDOI
Clinical development directions in oncolytic viral therapy
TL;DR: To date oncolytic virotherapy has shown to be safe, and has generated clinical responses in tumors that are resistant to chemotherapy or radiotherapy.