Journal ArticleDOI
Visceral perception in irritable bowel syndrome : rectal and gastric responses to distension and serotonin type 3 antagonism
Jaime Zighelboim,Nicholas J. Talley,Sidney F. Phillips,William S. Harmsen,Alan R. Zinsmeister +4 more
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TLDR
It is concluded that in this group of psychologically normal patients with irritable bowel syndrome, who were not chronic health-care seekers, visceral perception was normal, and ondansetron did not alter gut perception in health or in irritables bowel syndrome.Abstract:
We wished to determine if visceral perception in the rectum and stomach is altered in patients with irritable bowel syndrome and to evaluate the effects on visceral sensation of 5-HT3 receptor blockade. Twelve community patients with diarrhea-predominant irritable bowel syndrome and 10 healthy controls were studied in a double-blind, randomized, placebo-controlled study. Using two barostats, the stomach and rectum were distended, with pressure increments of 4 mm Hg, from 10 to 26 mm Hg; visceral perception was measured on an ordinal scale of 0–10. Personality traits were measured using standard psychological methods, and somatic pain was evaluated by immersion of the nondominant hand in cold water. The effect of 5-HT3 antagonism was tested with a single intravenous dose of ondansetron at 0.15 mg/kg. Gastric perception was higher in irritable bowel syndrome, but rectal distension was perceived similarly in irritable bowel syndrome and controls. Pain tolerance to cold water was also similar in irritable bowel syndrome and controls. Ondansetron induced rectal relaxation and increased rectal compliance but did not significantly alter gastric compliance or visceral perception. Psychological test scores were similar in patients and controls. We conclude that in this group of psychologically normal patients with irritable bowel syndrome, who were not chronic health-care seekers, visceral perception was normal. Ondansetron did not alter gut perception in health or in irritable bowel syndrome.read more
Citations
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AGA technical review on irritable bowel syndrome
TL;DR: Psychosocial factors, although not part of IBS per se, have an important role in modulating the illness experience and its clinical outcome.
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The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders
Michael D. Gershon,Jan Tack +1 more
TL;DR: Serotonin is an important gastrointestinal signaling molecule as mentioned in this paper, which is used by enterochromaffin (EC) cells to activate intrinsic and extrinsic primary afferent neurons to initiate peristaltic and secretory reflexes and transmit information to the central nervous system.
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Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?
TL;DR: Multivariate statistical analyses suggest that gastrointestinal disorders, psychiatric disorders, and nongastrointestinal somatic disorders are distinct disorders and not manifestations of a common somatization disorder, but their strong comorbidity suggests a common feature important to their expression, which is most likely psychological.
Journal ArticleDOI
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Robin C. Spiller,Robin C. Spiller,Qasim Aziz,Francis Creed,Anton Emmanuel,Lesley A. Houghton,Pali Hungin,Roger Jones,D Kumar,Greg Rubin,Nigel Trudgill,Peter J. Whorwell +11 more
TL;DR: Better ways of identifying which patients will respond to specific treatments are urgently needed for the assessment and management of adult patients with irritable bowel syndrome.
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Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial
Michael Camilleri,Northcutt Allison Ruth,Steven Kong,George E. Dukes,David J. McSorley,Allen W. Mangel +5 more
TL;DR: Alosetron was well tolerated and clinically effective in alleviating pain and bowel-related symptoms in this population of women with IBS.
References
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