Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis.
Marcos Emanoel Pereira,Alialdo Dantas Damascena,Laylla Mirella Galvão Azevedo,Tarcio de Almeida Oliveira,Jerusa da Mota Santana +4 more
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TLDR
A positive association between vitamin D deficiency and the severity of the disease was observed and was identified that severe cases of COVID-19 present 64% (or 1.64; 95% CI = 1.30–2.09) moreitamin D deficiency compared with mild cases.Abstract:
There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in people with the disease. Five online databases-Embase, PubMed, Scopus, Web of Science, ScienceDirect and pre-print Medrevix were searched. The inclusion criteria were observational studies measuring serum vitamin D in adult and elderly subjects with COVID-19. The main outcome was the prevalence of vitamin D deficiency in severe cases of COVID-19. We carried out a meta-analysis with random effect measures. We identified 1542 articles and selected 27. Vitamin D deficiency was not associated with a higher chance of infection by COVID-19 (OR = 1.35; 95% CI = 0.80-1.88), but we identified that severe cases of COVID-19 present 64% (OR = 1.64; 95% CI = 1.30-2.09) more vitamin D deficiency compared with mild cases. A vitamin D concentration insufficiency increased hospitalization (OR = 1.81, 95% CI = 1.41-2.21) and mortality from COVID-19 (OR = 1.82, 95% CI = 1.06-2.58). We observed a positive association between vitamin D deficiency and the severity of the disease.read more
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Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis.
TL;DR: There was a positive trend between serum 25(OH)D level < 20 ng/ml and an increased risk of mortality, ICU admission, invasive ventilation, non-invasive ventilation or SARS-CoV-2 positivity, however, these associations were not statistically significant.
Journal ArticleDOI
Vitamin D supplementation for the treatment of COVID-19: a living systematic review.
Julia Kristin Stroehlein,Julia Wallqvist,Claire Iannizzi,Agata Mikolajewska,Maria-Inti Metzendorf,Carina Benstoem,Patrick Meybohm,Marie Becker,Nicole Skoetz,Miriam Stegemann,Vanessa Piechotta +10 more
TL;DR: The role of vitamin D supplementation as a treatment for COVID-19 has been a subject of considerable discussion as discussed by the authors, and a thorough understanding of the current evidence regarding the effectiveness and safety of supplementing people with COVID19 based on randomised controlled trials is required.
Journal ArticleDOI
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study.
TL;DR: In this paper, the associations between cholecalciferol or calcifediol supplementation, serum 25-hydroxyvitamin D (25OHD) levels and COVID-19 outcomes in a large population were analyzed using multivariate Cox proportional regression.
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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Journal ArticleDOI
Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
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