Vitamin D During Pregnancy and Infancy and Infant Serum 25-Hydroxyvitamin D Concentration
Cameron C. Grant,Alistair W. Stewart,Robert Scragg,Tania Milne,Judy Rowden,Alec Ekeroma,Clare R Wall,Edwin A. Mitchell,Sue Crengle,Adrian Trenholme,Julian Crane,Carlos A. Camargo +11 more
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Daily vitamin D supplementation during pregnancy and then infancy with 1000/400 IU or 2000/800 IU increases the proportion of infants with 25(OH)D ≥20 ng/mL, with the higher dose sustaining this increase for longer.Abstract:
OBJECTIVE: To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥20 ng/mL during infancy. METHODS: A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks’ gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D 3 1000/400 IU, or vitamin D 3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measured at enrollment, 36 weeks’ gestation, in cord blood, and in infants at 2, 4, and 6 months of age. RESULTS: Two-hundred-and-sixty pregnant women were randomized. At enrollment, the proportions with serum 25(OH)D ≥20 ng/mL for placebo, lower-dose, and higher-dose groups were 54%, 64%, and 55%, respectively. The proportion with 25(OH)D ≥20 ng/mL was larger in both intervention groups at 36 weeks’ gestation (50%, 91%, 89%, P P P P = .004), but only in the higher-dose group at age 6 months (74%, 82%, 89%, P = .07; higher dose versus placebo P = .03, lower dose versus placebo P = .21). CONCLUSIONS: Daily vitamin D supplementation during pregnancy and then infancy with 1000/400 IU or 2000/800 IU increases the proportion of infants with 25(OH)D ≥20 ng/mL, with the higher dose sustaining this increase for longer.read more
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Vitamin D supplementation for women during pregnancy
TL;DR: In this paper, the effect of supplementing with vitamin D alone or in combination with calcium or other vitamins and minerals given to women during pregnancy can safely improve maternal and neonatal outcomes.
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Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery
TL;DR: This review addresses the current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery and the impacts that these adaptations have on biochemical and hormonal parameters of mineralHomeostasis.
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Global summary of maternal and newborn vitamin D status - a systematic review.
TL;DR: By global region, average 25(OH)D concentration varies threefold in pregnant women and newborns, and prevalence of 25( OH)D’s<50 and <25 nmol L(-1) varies eightfold innant women and three fold in newborns.
Journal ArticleDOI
Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones
TL;DR: A switch in the regulation of mineral homeostasis is triggered by loss of the placenta and a postnatal fall in serum calcium, and is followed in sequence by a rise in PTH and then an increase in calcitriol.
Journal ArticleDOI
Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians
Giuseppe Saggese,Francesco Vierucci,Flavia Prodam,Fabio Cardinale,Irene Cetin,Elena Chiappini,Gian Luigi De' Angelis,Maddalena Massari,Emanuele Miraglia del Giudice,Michele Miraglia Del Giudice,Diego Peroni,Luigi Terracciano,Rino Agostiniani,Domenico Careddu,Daniele Giovanni Ghiglioni,Gianni Bona,Giuseppe Di Mauro,Giovanni Corsello +17 more
TL;DR: An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplements to provide a practical approach to vitamin D supplementation for infants, children and adolescents.
References
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Book
Dietary Reference Intakes for Calcium and Vitamin D
TL;DR: The evidence supported a role for these nutrients in bone health but not in other health conditions, and there is emerging evidence that too much of these nutrients may be harmful.
Journal ArticleDOI
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
Dietary Reference Intakes for Calcium and Vitamin D
TL;DR: The purpose of this article is to cover exhaustively the potential health outcomes of these essential nutrients not just in bone health but also in overall health condition of an individual.
Journal ArticleDOI
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
TL;DR: Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
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