Vitellogenin functions as a multivalent pattern recognition receptor with an opsonic activity.
TLDR
This study shows that fish Vg plays an integrative function in regulating immunity via its pleiotropic effects on both recognizing pathogen-associated molecular patterns and promoting macrophage phagocytosis, and supports the notion that factors normally involved in control of female reproduction are associated with immunity in organisms that rely on Vg for oocyte development.Abstract:
Background
Vitellogenin (Vg), a major reproductive protein, has been associated with infection-resistant response in fish. However, the underlying mechanisms by which Vg is involved in anti-infectious response are not understood.
Methodology/Results
By both protein-microbe interaction analysis and enzyme-linked immunosorbent assay as well as phagocytosis test, we demonstrate for the first time that fish Vg acts as a pattern recognition molecule with multiple specificities that can recognize bacteria as well as fungus rather than self components from fish, and functions as an opsonin that can enhance macrophage phagocytosis.
Conclusions
This study shows that fish Vg plays an integrative function in regulating immunity via its pleiotropic effects on both recognizing pathogen-associated molecular patterns and promoting macrophage phagocytosis. It also supports the notion that factors normally involved in control of female reproduction are associated with immunity in organisms that rely on Vg for oocyte development.read more
Citations
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Journal ArticleDOI
The oyster immunity.
TL;DR: The maternally derived immunity and immune priming suggest the adaptability of oyster immunity, and the primitive catecholaminergic, cholinergic, neuropeptides, GABAergic and nitric oxidase system possibly make oysters ideal model for studying the origin and evolution of immune system and the neuroendocrine‐immune regulatory network in lower invertebrates.
Journal ArticleDOI
The major yolk protein vitellogenin interferes with the anti-plasmodium response in the malaria mosquito Anopheles gambiae.
Martin K. Rono,Miranda M. A. Whitten,Miranda M. A. Whitten,Miranda M. A. Whitten,Mustapha Oulad-Abdelghani,Elena A. Levashina,Elena A. Levashina,Elena A. Levashina,Eric Marois,Eric Marois,Eric Marois +10 more
TL;DR: Functional gene analysis in malaria mosquitoes reveals molecules underpinning the trade-off between efficient reproduction and the antiparasitic response.
Journal ArticleDOI
Requirement for amino acids in ontogeny of fish
TL;DR: The importance of amino acids for the intermediary metabolism of fish embryos and larvae is reviewed and the specialization of the lysosomal pathway involved in the uptake and degradation of yolk proteins is addressed, where amino acids have been shown to be the preferred catabolic substrate.
Journal ArticleDOI
Vitellogenin, a multivalent sensor and an antimicrobial effector.
TL;DR: Recent developments in the understanding of Vg are discussed, which should provide new insights into the mechanisms of host defense, and reveal if they can be used as alternative strategies promoting the immunity of cultured fish as well as developing embryos.
Journal ArticleDOI
Regulation of vitellogenin genes in insects
TL;DR: The role of Vg genes as a target of endocrine disruptors will be addressed, and the molecular mechanism of Vn gene regulation will be discussed, which is the main nutritional reserve for the developing embryo.
References
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